Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk
Autor: | Ricardo Usategui-Martín, Salvador Pastor-Idoate, A.J. Chamorro, Itziar Fernández, Rogelio González-Sarmiento, Miguel Marcos-Martin, Jose-Carlos Pastor, Ivan Fernandez-Bueno |
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Přispěvatelé: | Junta de Castilla y León, European Commission |
Rok vydání: | 2019 |
Předmět: |
Oncology
Male Heredity genetic structures Research Quality Assessment Genome-wide association study Macular Degeneration Mathematical and Statistical Techniques Risk Factors Genotype Medicine and Health Sciences Odds Ratio Geriatric Ophthalmology Promoter Regions Genetic Aged 80 and over Multidisciplinary Retinal Degeneration Statistics Genomics Metaanalysis Research Assessment Middle Aged Extracellular Matrix Genetic Mapping Meta-analysis Physical Sciences Medicine Retinal Disorders Matrix Metalloproteinase 2 Female Cellular Structures and Organelles Research Article medicine.medical_specialty Science Variant Genotypes Genes Recessive Research and Analysis Methods Polymorphism Single Nucleotide Sensitivity and Specificity Internal medicine Genetic model medicine Genetics Genome-Wide Association Studies Humans Allele Statistical Methods Alleles Aged Models Genetic business.industry Case-control study Biology and Life Sciences Computational Biology Human Genetics Odds ratio Cell Biology Macular degeneration medicine.disease Genome Analysis eye diseases Ophthalmology Geriatrics Genetic Loci Macular Disorders Case-Control Studies Genetics of Disease sense organs business Mathematics |
Zdroj: | PLoS ONE Digital.CSIC. Repositorio Institucional del CSIC instname PLoS ONE, Vol 14, Iss 3, p e0213624 (2019) |
Popis: | © 2019 Usategui-Martín et al. [Purpose]: Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD. [Methods]: We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis. [Results]: Our results showed that there was no significant association between the variant T allele (p-value = 0.10, OR [95%CI] = 0.95 [0.82–1.10]) or the CT+TT genotype (p-value = 0.16, OR [95%CI] = 0.92 [0.76–1.12]) of rs243865 MMP-2 polymorphism and the presence of AMD. [Conclusions]: The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD. The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility. This work was supported in part by a grant from the Consejería de Educación, Junta de Castilla y León, Fondos FEDER (VA077P17) (JCP) and from Gerencia Regional de Salud de Castilla y León (INT/M/06/18) (AJC). |
Databáze: | OpenAIRE |
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