Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk

Autor: Ricardo Usategui-Martín, Salvador Pastor-Idoate, A.J. Chamorro, Itziar Fernández, Rogelio González-Sarmiento, Miguel Marcos-Martin, Jose-Carlos Pastor, Ivan Fernandez-Bueno
Přispěvatelé: Junta de Castilla y León, European Commission
Rok vydání: 2019
Předmět:
Oncology
Male
Heredity
genetic structures
Research Quality Assessment
Genome-wide association study
Macular Degeneration
Mathematical and Statistical Techniques
Risk Factors
Genotype
Medicine and Health Sciences
Odds Ratio
Geriatric Ophthalmology
Promoter Regions
Genetic
Aged
80 and over
Multidisciplinary
Retinal Degeneration
Statistics
Genomics
Metaanalysis
Research Assessment
Middle Aged
Extracellular Matrix
Genetic Mapping
Meta-analysis
Physical Sciences
Medicine
Retinal Disorders
Matrix Metalloproteinase 2
Female
Cellular Structures and Organelles
Research Article
medicine.medical_specialty
Science
Variant Genotypes
Genes
Recessive
Research and Analysis Methods
Polymorphism
Single Nucleotide
Sensitivity and Specificity
Internal medicine
Genetic model
medicine
Genetics
Genome-Wide Association Studies
Humans
Allele
Statistical Methods
Alleles
Aged
Models
Genetic
business.industry
Case-control study
Biology and Life Sciences
Computational Biology
Human Genetics
Odds ratio
Cell Biology
Macular degeneration
medicine.disease
Genome Analysis
eye diseases
Ophthalmology
Geriatrics
Genetic Loci
Macular Disorders
Case-Control Studies
Genetics of Disease
sense organs
business
Mathematics
Zdroj: PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE, Vol 14, Iss 3, p e0213624 (2019)
Popis: © 2019 Usategui-Martín et al.
[Purpose]: Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD. [Methods]: We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis. [Results]: Our results showed that there was no significant association between the variant T allele (p-value = 0.10, OR [95%CI] = 0.95 [0.82–1.10]) or the CT+TT genotype (p-value = 0.16, OR [95%CI] = 0.92 [0.76–1.12]) of rs243865 MMP-2 polymorphism and the presence of AMD. [Conclusions]: The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD. The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility.
This work was supported in part by a grant from the Consejería de Educación, Junta de Castilla y León, Fondos FEDER (VA077P17) (JCP) and from Gerencia Regional de Salud de Castilla y León (INT/M/06/18) (AJC).
Databáze: OpenAIRE
Externí odkaz: