Analyses of hind leg skeletons in human growth hormone transgenic rats
| Autor: | Erica Yada, Hiroyuki Hozumi, Keitaro Yamanouchi, Masugi Nishihara, Chiori Ueno |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Aging medicine.medical_specialty Period (gene) Osteocalcin Osteoporosis Hindlimb Biology Growth hormone Biochemistry Bone and Bones Animals Genetically Modified Endocrinology Bone Density Internal medicine Genetics medicine Animals Molecular Biology Bone mineral Human Growth Hormone Phosphorus Cell Biology medicine.disease Skeleton (computer programming) Rats medicine.anatomical_structure Growth Hormone Models Animal Calcium Cortical bone Transgenic Rats |
| Zdroj: | Experimental Gerontology. 39:1179-1188 |
| ISSN: | 0531-5565 |
| Popis: | Growth hormone (GH) is essential in the development and growth of the skeleton and for the maintenance of bone mass and density, and its secretion is known to decline with aging. We have previously produced transgenic rats with low circulating GH that represent several age-associated phenotypes such as obesity, insulin-resistance and leptin-resistance. In the present study, the cross-sectional area, bone mineral density, and strength indexes of the hind leg skeletons of the transgenic rats were examined by an X-ray computed tomography scanning. The mean cross-sectional area of the transgenic rats showed no increase after 2 months old up to 8 months old and the strength indexes were significantly lower than their non-transgenic siblings at all ages examined. The trabecular bone mineral density in the transgenic rats drastically decreased at 8 months old, while the cortical bone mineral density was comparable to the non-transgenic rats, suggesting the onset of osteoporosis at this period. The results obtained in this study indicate that the transgenic rats could be useful model to gain insight into the complex mechanism leading to osteoporosis with aging. |
| Databáze: | OpenAIRE |
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