Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice
| Autor: | C Y Hayashida, Cyril Y. Bowers, Paolo Bartolini, Sergio P. A. Toledo, Rodrigo A. Toledo, Viviane C. Longuini, Cibele N. Peroni, Nancy Nascimento |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Receptors Neuropeptide Leptin Heterozygote medicine.medical_specialty Somatotropic cell Biology Growth hormone deficiency Mice Random Allocation GHRP-2 Receptors Pituitary Hormone-Regulating Hormone Growth hormone secretagogue Internal medicine medicine Animals Receptor Analysis of Variance General Medicine medicine.disease Mice Mutant Strains Ghrelin Little mouse GH Mice Inbred C57BL Disease Models Animal Basic Research Endocrinology Hormone receptor Growth Hormone Female GHRH-R Oligopeptides Hormone |
| Zdroj: | Clinics, Volume: 67, Issue: 3, Pages: 265-272, Published: 2012 Clinics |
| Popis: | OBJECTIVE: To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormone-releasing hormone receptors. MATERIALS AND METHODS: The responses of serum growth hormone to acutely injected growth hormone-releasing P-2 in lit/lit mice, which represent a model of GH deficiency arising from mutated growth hormone-releasing hormone-receptors, were compared to those observed in the heterozygous (lit/+) littermates and wild-type (+/+) C57BL/6J mice. RESULTS: After the administration of 10 mcg of growth hormone-releasing P-2 to lit/lit mice, a growth hormone release of 9.3±1.5 ng/ml was observed compared with 1.04±1.15 ng/ml in controls (p |
| Databáze: | OpenAIRE |
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