Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives

Autor:	Antonia Iazzetti, Antonio Arcadi, Stefano Dessalvi, Giancarlo Fabrizi, Antonella Goggiamani, Federico Marrone, Andrea Serraiocco, Alessio Sferrazza, Karim Ullah
Rok vydání:	2022
Předmět:	2-dihydro-3H-pyrrolo[1 1 2-dihydro-3H-pyrrolo[1 2-a]indol-3-ones indolyl methides palladium catalysis domino reactions Settore CHIM/06 - CHIMICA ORGANICA 2-a]indol-3-ones Physical and Theoretical Chemistry Catalysis General Environmental Science
Zdroj:	Catalysts; Volume 12; Issue 12; Pages: 1516
ISSN:	2073-4344
DOI:	10.3390/catal12121516
Popis:	A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.
Databáze:	OpenAIRE
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