Pharmacokinetics of Salbutamol Delivered from the Unit Dose Dry Powder Inhaler: Comparison with the Metered Dose Inhaler and Diskus Dry Powder Inhaler
| Autor: | Kylie Riddell, Shashidhar Joshi, Rashmi Mehta, Alison Moore, Robert Chan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Cmax Pharmaceutical Science Lactose Excipients 03 medical and health sciences Young Adult 0302 clinical medicine Pharmacokinetics Administration Inhalation Medicine Humans Pharmacology (medical) Albuterol Tissue Distribution 030212 general & internal medicine Metered Dose Inhalers Lung Cross-Over Studies business.industry Healthy subjects Dry Powder Inhalers Middle Aged Metered-dose inhaler Dry-powder inhaler Bronchodilator Agents 030228 respiratory system Anesthesia Area Under Curve Plasma concentration Salbutamol Primary treatment Female business medicine.drug |
| Zdroj: | Journal of aerosol medicine and pulmonary drug delivery. 30(3) |
| ISSN: | 1941-2703 |
| Popis: | To compare the systemic exposure of salbutamol following delivery from the unit dose dry powder inhaler (UD-DPI) system with that from the DiskusThis open-label, two-part, six-way crossover, randomized single-dose study in healthy subjects evaluated salbutamol systemic exposure of three dose strengths (using three inhalations: 3 × 150 μg [450 μg], 3 × 200 μg [600 μg], and 3 × 250 μg [750 μg]) and 2% of drug in lactose blends (1.6% and 1.0% [600 μg dose only] by weight) following delivery through the UD-DPI compared with systemic exposure from the Diskus and MDI (600 μg dose). Systemic exposure in the presence of charcoal block was also evaluated. Primary treatment comparisons were area under the concentration-time curve from time zero to 12 hours [AUCDelivery of salbutamol 600 μg from the UD-DPI resulted in total systemic exposure similar to that from the Diskus and approximately half of that from the MDI (AUCSalbutamol total systemic exposure following UD-DPI was similar to that from the Diskus and was lower than that following the MDI. The different blend formulations tested resulted in consistent salbutamol systemic exposure. The contribution of the lung and gut to systemic exposure revealed a different profile for the three inhaler platforms. These data suggest that the UD-DPI warrants further evaluation. |
| Databáze: | OpenAIRE |
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