Cardiac Resynchronization in Different Age Groups: A MADIT-CRT Long-Term Follow-Up Substudy

Autor: Ilan Goldenberg, Alon Barsheshet, Wojciech Zareba, Sabu Thomas, Helmut U. Klein, Yitschak Biton, Valentina Kutyifa, David T. Huang, Arthur J. Moss, Scott McNitt
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
genetic structures
Long term follow up
medicine.medical_treatment
Cardiac resynchronization therapy
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Statistics
Nonparametric
Cardiac Resynchronization Therapy
03 medical and health sciences
Geriatric cardiology
0302 clinical medicine
Age groups
Risk Factors
Internal medicine
Post-hoc analysis
medicine
Humans
Madit crt
cardiovascular diseases
030212 general & internal medicine
Aged
Randomized Controlled Trials as Topic
Aged
80 and over
Heart Failure
business.industry
Age Factors
Middle Aged
medicine.disease
Defibrillators
Implantable
Treatment Outcome
Heart failure
Cardiac resynchronization
cardiovascular system
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Zdroj: Journal of Cardiac Failure. 22:143-149
ISSN: 1071-9164
DOI: 10.1016/j.cardfail.2015.09.015
Popis: Cardiac resynchronization with defibrillators (CRT-D) reduces heart failure and mortality compared with defibrillators alone. Whether this applies to all ages is unclear.We assessed the association of age on heart failure and death as a post hoc analysis of the MADIT-CRT follow-up study, in which 1,281 patients with class I/II heart failure (HF) were randomized to CRT-D or implantable cardioverter-defibrillators alone. Different age groups (60, 60-74, and ≥75 years) were evaluated over 7 years for mortality and HF events. Among the 3 age groups, there were 399, 651, and 231 patients, respectively. We compared events with the use of a multivariate regression model. CRT-D compared with defibrillators alone significantly reduced the composite of HF or death across all age groups:60 years: relative risk reduction (RRR) = 36%; 60-74 years: RRR = 61%; ≥75 years: RRR = 56%. CRT-D significantly reduced HF in all age groups:60 years: RRR = 49%; 60-74 years: RRR = 62%; ≥75 years: RRR = 74%. CRT-D was associated with significant mortality reduction only in the 60-74 year age group: RRR = 59%.CRT-D reduced HF events and the composite of mortality or HF events during long-term follow-up in all age groups. CRT-D reduced mortality only in the 60-74 year age group.
Databáze: OpenAIRE
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