Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli
| Autor: | Vongsavanh Phongsisay, Shuji Fujimoto, Hiromitsu Hara |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Glycoconjugate
Immunology Human pathogen medicine.disease_cause Campylobacter jejuni Microbiology Immune system medicine Escherichia coli Animals Humans Receptor Molecular Biology chemistry.chemical_classification Inflammation biology NF-kappa B biology.organism_classification Virology Toll-Like Receptor 2 Mice Inbred C57BL Toll-Like Receptor 4 TLR2 chemistry TLR4 Cytokines Endopeptidase K Glycoconjugates |
| Zdroj: | Molecular immunology. 64(1) |
| ISSN: | 1872-9142 |
| Popis: | Campylobacter jejuni causes gastroenteritis and autoimmune neuropathy Guillain–Barre syndrome. The mechanism by which C. jejuni infection results in such the hyperimmunity is not completely understood. Host immunity plays an important role in the disease pathogenesis; however, little is known how immune system recognizes this human pathogen. In this study, we report that Toll-like receptors recognize distinct proteinase K-resistant glycoconjugates in C. jejuni and Escherichia coli. Lipopolysaccharide is solely proteinase-resistant glycoconjugate in E. coli. In contrast, C. jejuni possesses at least five different components that are resistant to proteinase digestion and are capable of inducing NF-κB activation through TLR2 and TLR4. Possession of multiple activators of Toll-like receptors may be the unique strategy of C. jejuni to trigger hyperimmunity. |
| Databáze: | OpenAIRE |
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