Low serum pancreatic amylase levels as a novel latent risk factor for colorectal adenoma in non‐alcohol drinkers
| Autor: | Yoshiyuki Ueno, Yasuhiko Abe, Takayuki Sakai, Naoko Mizumoto, Minami Ito, Matsuki Umehara, Takashi Kon, Makoto Yagi, Yusuke Onozato, Yu Sasaki, Shoichi Nishise |
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| Rok vydání: | 2021 |
| Předmět: |
Adenoma
medicine.medical_specialty Pancreatic disease genetic structures Hepatology Colorectal cancer business.industry Gastroenterology Colorectal adenoma medicine.disease Obesity Cross-Sectional Studies Insulin resistance Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Amylases Nonalcoholic fatty liver disease medicine Humans Risk factor Colorectal Neoplasms business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 37:660-668 |
| ISSN: | 1440-1746 0815-9319 |
| Popis: | Obesity, insulin resistance, and metabolic alterations increase the risk of colorectal cancer and adenoma (CRA). Non-alcoholic fatty liver disease (NAFLD) or pancreatic disease (NAFPD) shares many risk factors with CRA that may have significant roles in its development; however, the relationship between CRA and NAFLD/NAFPD remains unclear.This cross-sectional study recruited 712 eligible participants without current drinking who had undergone total colonoscopy as part of a health checkup. These participants were classified into a CRA group (n = 236) and a control group (n = 439), which consisted of individuals without CRA and a history of polyp resection. NAFLD and NAFPD were diagnosed based on abdominal ultrasonography findings.Non-alcoholic fatty liver disease was observed more frequently in individuals with CRA than in the control group (55.9% vs 41.6%, P 0.01). There was no significant association between NAFPD and CRA; however, serum pancreatic amylase (P-amylase) levels were significantly lower in individuals with CRA. Although NAFLD was one of the factors increasing the presence of CRA (odds ratio [OR], 1.50; 95% confidence interval [CI], 1.07-2.10), low P-amylase levels were significantly associated with the presence of CRA (OR, 1.73; 95% CI, 1.04-2.88) independent of age, sex, current smoking, obesity, metabolic alterations including insulin resistance, and NAFLD.Low serum P-amylase levels were a possible independent risk factor for CRA in the present study. The latent pancreatic exocrine-endocrine-gut relationship was considered a novel pathway involved in obesity-related CRA development, in non-alcoholic individuals. |
| Databáze: | OpenAIRE |
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