Localization of the transcription factor SP1 gene to human chromosome 12q12→q13.2

Autor:	Aldon J. Lusis, Richard B. Gaynor, B.-H. Shieh, I J Klisak, R. S. Sparkes
Rok vydání:	1993
Předmět:	Male Genetics Zinc finger Sp1 transcription factor Chromosomes Human Pair 12 Sp1 Transcription Factor GATA4 Chromosome Mapping Promoter TCF4 Hybrid Cells Biology Mice Sp3 transcription factor Sigma factor TAF2 Animals Humans Molecular Biology In Situ Hybridization Genetics (clinical)
Zdroj:	Cytogenetic and Genome Research. 64:210-212
ISSN:	1424-859X 1424-8581
Popis:	The cellular transcription factor SP 1 binds to critical regulatory elements in a variety of cellular and viral promoters. The gene encoding the ∼100-kDa SP 1 protein contains zinc finger DNA-binding domains and glutamine-activation domains. Since SP1 is involved in the regulation of a variety of cellular genes, we wished to determine its chromosomal localization. Southern blot analysis of genomic DNA from a panel of mouse × human somatic cell hybrids indicated that SP1 was localized to chromosome 12. In situ hybridization allowed the localization of the gene encoding SP 1 to human chromosome 12q12→q13.2, with 12q13.1 being the most probable location.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2f9140555a0b20ff347740f93f47cf https://doi.org/10.1159/000133578 Zobrazit plný text záznamu