Uric acid in chronic coronary syndromes: Relationship with coronary artery disease severity and left ventricular diastolic parameter
| Autor: | Roberto Pirola, Emanuela Piccaluga, Antonella Moreo, Maria Grazia Valsecchi, Paola Rebora, Alessandro Maloberti, Giacomo Piccalò, Fabrizio Oliva, Stefano Nava, Jacopo Oreglia, Francesco Soriano, Benedetta De Chiara, P. Vallerio, Angelo Racioppi, Elena Tassistro, Cristina Giannattasio, Irene Bossi |
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| Přispěvatelé: | Maloberti, A, Bossi, I, Tassistro, E, Rebora, P, Racioppi, A, Nava, S, Soriano, F, Piccaluga, E, Piccalo, G, Oreglia, J, Vallerio, P, Pirola, R, De Chiara, B, Oliva, F, Moreo, A, Valsecchi, M, Giannattasio, C |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Diastole Medicine (miscellaneous) 030209 endocrinology & metabolism Chronic coronary syndrome Disease Hyperuricemia 030204 cardiovascular system & hematology Coronary Angiography Severity of Illness Index Coronary artery disease Ventricular Function Left 03 medical and health sciences chemistry.chemical_compound Ventricular Dysfunction Left 0302 clinical medicine Internal medicine Medicine Humans Myocardial infarction Aged Retrospective Studies Nutrition and Dietetics business.industry Middle Aged medicine.disease Prognosis Coronary arteries medicine.anatomical_structure Cross-Sectional Studies chemistry Echocardiography Cardiology Uric acid Diastolic dysfunction Female Cardiology and Cardiovascular Medicine business Early phase Biomarkers Artery |
| Popis: | Background and aims Uric Acid (UA) has been related to the development of Cardio-Vascular (CV) events in patients affected by Chronic Coronary Syndromes (CCS). Among various hypothesis, two arise: UA may negatively act on coronary artery determining a higher degree of atherosclerotic disease, and/or on heart determining a higher prevalence of diastolic dysfunction. Both the above hypothesized effects are object of our investigation. Methods and results 231 patients who were admitted to the cardiological department of the Niguarda Hospital (Milan, Italy) for CCS from January 2017 to June 2018 were enrolled. Coronary atherosclerotic burden was evaluated from coronary angiography as the number and type of involved vessels, as well as with both Gensini and Syntax scores. All subjects underwent a complete echocardiogram. At unadjusted and adjusted/multivariable analysis, UA levels were not significantly associated with variables analysed from the coronary angiography (number and type of vessels involved, neither the Gensini and Syntax scores) as well as with echocardiographic parameters regarding systolic and diastolic function. Conclusions In conclusion, the main finding of our work is the absence of a role for UA in determining coronary arteries disease as well as LV diastolic dysfunction in CCS subjects. Taking together the results of previous studies with ours, we hypothesize that UA could act on heart (both on coronary arteries and on LV function) in an early phase of the disease, whereas while in the advanced stages other factors (previous myocardial infarction, previous myocardial revascularization and so on) may overshadow its effects. |
| Databáze: | OpenAIRE |
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