Association of autoantibodies against small nuclear ribonucleoproteins (snRNPs) with symptomatic Toxocara canis infestation
| Autor: | Andreas Obwaller, Gerhard Wiedermann, Julia Walochnik, Herbert Auer, Horst Aspöck, Michael Duchêne |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Immunoblotting Immunology Antibodies Helminth medicine.disease_cause Immunofluorescence Asymptomatic Statistics Nonparametric Autoimmunity Antigen Cell Line Tumor parasitic diseases medicine Animals Humans Helminths Child Fluorescent Antibody Technique Indirect Autoantibodies Toxocariasis biology medicine.diagnostic_test Autoantibody Toxocara canis Middle Aged Ribonucleoproteins Small Nuclear biology.organism_classification Staining Antibodies Antinuclear Child Preschool Female Parasitology medicine.symptom |
| Zdroj: | Parasite Immunology. 26:327-333 |
| ISSN: | 1365-3024 0141-9838 |
| DOI: | 10.1111/j.0141-9838.2004.00716.x |
| Popis: | SUMMARY Several studies have demonstrated the occurrence of autoantibodies in the course of infestations with helminth parasites and a number of target proteins have been identified. Sera from patients suffering from toxocarosis, a disease caused by the parasitic roundworm Toxocara canis, and from healthy individuals were tested for autoantibodies by immunofluorescence and immunoblot assays using HEp-2 cells as antigen. A considerable proportion of the sera from patients with toxocarosis-associated symptoms were autoantibody-positive, with a speckled staining pattern in the immunofluorescence test (62%) and with anti-snRNP reactivity in the immunoblot assay (98%). In contrast, significantly fewer sera from asymptomatic individuals scored positive in these assays (18% in the immunofluorescence test, P |
| Databáze: | OpenAIRE |
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