Analysis of FOXO1A and FOXO3A gene allele association with human longevity
| Autor: | I. A. Tuktarova, V. V. Erdman, R. Sh. Somova, Timur R. Nasibullin, Olga E. Mustafina |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics media_common.quotation_subject Longevity Biology Logistic regression 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Genotype Allele Transcription Factor Gene Genotyping Gene media_common Genetic association |
| Zdroj: | Scopus-Elsevier ResearcherID |
| ISSN: | 1608-3369 1022-7954 |
| DOI: | 10.1134/s1022795416020034 |
| Popis: | Seeking human longevity association with gene polymorphisms in transcription factors in the Tatar ethnic group, we conducted an analysis for age-related genotype, frequencies in polymorphic sites of FOXO1A (rs4943794, 72327C>G) and FOXO3A (rs3800231, 35-2764A>G) genes. Genotyping was conducted by using the PCR-RFLP approach. According to the results of logistic regression analysis, during maturity and old age periods, a decrease in the number of FOXO1A*G/*G (OR = 0.984, P = 0.004) genotype carriers occurs and an increase in the number of FOXO1A*C/*G (OR = 1.035, P = 0.014) and FOXO1A*C/*C (OR = 1.024, P = 0.033) genotype carriers occurs in the sample of subjects before gender adjustments. In the sample of long-livers, the number of FOXO1A*C/*C (OR = 0.772, P = 0.028) genotype carriers decreased among women, while the number of FOXO3A*G/*G (OR = 1.008, P = 0.0001) genotype carriers increased among both men and women. Therefore, the FOXO1A gene polymorphic site rs4943794 is associated with an acquisition of old and senescent age in a sample before gender adjustments and with women's longevity. FOXO3A gene polymorphic site rs3800231 is associated with longevity in both women and men. |
| Databáze: | OpenAIRE |
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