East Asians Variant Mitochondrial Aldehyde Dehydrogenase 2 Genotype Exacerbates Nitrate Tolerance in Patients With Coronary Spastic Angina
| Autor: | Izumi Kusumegi, Fumihito Kugimiya, Yuji Mizuno, Michihiro Yoshimura, Hirofumi Yasue, Makoto Shono, Eisaku Harada, Kenji Kinoshita |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Vasodilator Agents Drug Resistance Coronary Vasospasm Aldehyde dehydrogenase 030204 cardiovascular system & hematology Gastroenterology Angina Pectoris Coronary artery disease Angina Nitroglycerin 03 medical and health sciences 0302 clinical medicine Asian People Japan Internal medicine Genotype Spastic medicine Humans Endothelial dysfunction Aged Morning ALDH2 Polymorphism Genetic biology business.industry Aldehyde Dehydrogenase Mitochondrial General Medicine Middle Aged medicine.disease 030104 developmental biology Vasoconstriction cardiovascular system biology.protein Female Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
| Zdroj: | Circulation Journal. 84:479-486 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-19-0989 |
| Popis: | BACKGROUND Aldehyde dehydrogenase 2 (ALDH2) plays a central role in the biotransformation of glyceryl trinitrate (GTN) or nitroglycerin, which is widely used for the treatment of coronary artery disease (CAD). The deficient variant ALDH2 genotype (ALDH2*2) is prevalent among East Asians. This study examined whether there are differences in nitroglycerine-mediated dilation (NMD) and flow-mediated dilation (FMD) response between wildALDH2*1/*1and variantALDH2*2patients with CAD.Methods and Results:The study subjects comprised 55 coronary spastic angina (CSA) patients, confirmed by coronary angiography and intracoronary injection of acetylcholine (42 men and 13 women, mean age 68.0±9.0 years). They underwent NMD and FMD tests in the morning before and after continuous transdermal GTN administration for 48 h. NMD was lower at baseline inALDH2*2than in theALDH2*1/*1group (P=0.0499) and decreased significantly in both groups (P |
| Databáze: | OpenAIRE |
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