Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment
| Autor: | Gan Qiao, Xiukun Lin, Ye Tian, Anguo Wu, Xiaoliang Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Protein moonlighting
Moonlighting Protein Enolase Antineoplastic Agents Review Applied Microbiology and Biotechnology Transduction (genetics) Structure-Activity Relationship transduction cascades Transcription (biology) Neoplasms Biomarkers Tumor Medicine Humans Molecular Biology Ecology Evolution Behavior and Systematics business.industry Binding protein Tumor Suppressor Proteins Enolase 1 Cancer Translation (biology) Cell Biology medicine.disease DNA-Binding Proteins Cancer treatment Phosphopyruvate Hydratase Cancer research business Protein Processing Post-Translational Function (biology) Developmental Biology Signal Transduction |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| Popis: | Enolase 1 (ENO1) is a moonlighting protein, function as a glycolysis enzyme, a plasminogen receptor and a DNA binding protein. ENO1 play an important role in the process of cancer development. The transcription, translation, post-translational modifying activities and the immunoregulatory role of ENO1 at the cancer development is receiving increasing attention. Some function model studies have shown that ENO1 is a potential target for cancer treatment. In this review, we provide a comprehensive overview of the characterization, function, related transduction cascades of ENO1 and its roles in the pathophysiology of cancers, which is a consequence of ENO1 signaling dysregulation. And the development of novels anticancer agents that targets ENO1 may provide a more attractive option for the treatment of cancers. The data of sarcoma and functional cancer models indicates that ENO1 may become a new potential target for anticancer therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|