Role of the Kidney in the Production of a Low Molecular Weight Growth Factor (MW < 1000 Da): Experimental Study in the Pig
| Autor: | F. Maachi, A. Punga-Maole, F. Belleville, J. Hubert, B. Dousset, E. Junke, C. Jacob |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Swine Bilirubin medicine.medical_treatment Renal function Chick Embryo Kidney Critical Care and Intensive Care Medicine Nephrectomy Transplantation Autologous chemistry.chemical_compound Internal medicine medicine Animals Insulin-Like Growth Factor I Growth Substances Creatinine business.industry Growth factor food and beverages General Medicine Acute Kidney Injury Kidney Transplantation Transplantation Endocrinology medicine.anatomical_structure Liver chemistry Nephrology Biological Assay business Bilateral Nephrectomy |
| Zdroj: | Renal Failure. 17:339-347 |
| ISSN: | 1525-6049 0886-022X |
| DOI: | 10.3109/08860229509037600 |
| Popis: | Small peptide molecules known as low molecular weight growth factor (LMW-GF) have been identified in human serum. They enhance the effect of IGF-1 (insulin-like growth factor) on proteoglycan synthesis. In the present work we investigated the role played by the kidney in the production of LMW-GF, using the pig as an experimental model. Six pigs underwent bilateral nephrectomy followed 24 h later by orthotopic autotransplantation of the kidney. Renal and liver functions were evaluated by measurement of serum creatinine, urea, electrolytes, amino transferases (ASAT, ALAT), proteins, and bilirubin. LMW-GF was measured by bioassay using 11-day-old pelvic chick embryo cartilages. We observed that LMW-GF quickly disappeared from pig serum after nephrectomy and only reappeared when transplantation was successful. Reappearance of LMW-GF can precede improvement of renal function evaluated by plasma creatinine levels. These data appear to demonstrate that the kidney is involved in LMW-GF production. |
| Databáze: | OpenAIRE |
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