Balance features in Alzheimer's disease and amnestic mild cognitive impairment
| Autor: | Massimo Leandri, Sharon Cammisuli, Marina Simonini, Sergio Cammarata, Luigi Baratto, Jackie Campbell, Massimo Tabaton |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Disease Audiology Neuropsychological Tests orientation Alzheimer’s disease mild cognitive impairment postural balance stabilometry Alzheimer Disease medicine Humans In patient Cognitive impairment Psychiatry Vision Ocular Balance (ability) Aged Vestibular system Aged 80 and over Foot General Neuroscience Healthy subjects General Medicine Cognitive test Psychiatry and Mental health Clinical Psychology Female Analysis of variance Amnesia Geriatrics and Gerontology Psychology Cognition Disorders Psychomotor Performance |
| Popis: | We evaluated alterations of balance by stabilometry in patients with amnestic mild cognitive impairment (aMCI) and with mild-moderate Alzheimer's disease (AD). Fifteen patients with aMCI and 15 with mild AD were recruited according to the current diagnostic criteria. Fifteen healthy subjects of the same age range were recruited as controls. Stabilometry was carried out using a commercial 4 load cell platform. Statistical analysis of between group differences was performed using one-way analysis of variance for parametric data and Kruskal-Wallis tests for non-parametric data. Spearman correlation coefficients were used to investigate the association between cognitive test scores and stabilometric data. All stabilometry measures were significantly altered in mild AD patients compared to normal controls. Antero-posterior sway was found to be the most sensitive parameter, since it correlated with the ADAS-cog orientation subscale in AD patients, and also discriminated between aMCI and normal controls. Our study shows that impairment in balance is a feature not only of AD, but also of aMCI. The alterations found suggest that a progressive failure of the vestibular system, possibly linked to reduced hippocampal performance, may be responsible for such a feature. Further research must be focused on studying the predictive value of stabilometry in the conversion of aMCI. |
| Databáze: | OpenAIRE |
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