Deregulated Expression of Long Non-coding RNA HOX Transcript Antisense RNA (HOTAIR) in Egyptian Patients with Multiple Myeloma
| Autor: | Mohamed A Helwa, Samar M Kamal Eldin, Amira M. F. Shehata, Nahla F. Osman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Hematology business.industry HOTAIR 030204 cardiovascular system & hematology medicine.disease Long non-coding RNA Reverse transcriptase 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Internal medicine medicine Original Article Bone marrow business HOX Transcript Antisense RNA Progressive disease Multiple myeloma 030215 immunology |
| Zdroj: | Indian J Hematol Blood Transfus |
| Popis: | Increasing evidence of involvement of non-coding RNAs, especially long non-coding RNAs (lncRNAs), in the molecular biology of various malignancies have been recently reported. Their utilization as markers for diagnosis, prognosis and evaluation of treatment response was widely investigated. As the impact of lncRNA HOTAIR on multiple myeloma (MM) was not properly highlighted, we aimed to explore the expression levels of HOTAIR in three groups of MM patients and to analyze its relationship to different patients’ characteristics. Plasma samples were withdrawn from 24 newly diagnosed MM patients, 23 post-therapy patients in complete response (CR) or very good partial response (VGPR) and 15 patients who had either progressive disease (PD) or relapse. The expression of lncRNA HOTAIR in MM patients and 20 healthy controls was analyzed by quantitative reverse transcription polymerase chain reactions. HOTAIR was significantly upregulated in newly diagnosed and PD/relapse categories in comparison with controls and MM patients who had achieved CR or VGPR (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|