LONG-TERM RESULTS OF AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROID TRANSPLANTATION FOR THE TREATMENT OF EXUDATIVE AND ATROPHIC MACULOPATHIES
| Autor: | Sajish Pinackatt, Attilio Di Salvatore, Daniele Cardillo, Andrea Baldi, Alessandro Finzi, Rino Frisina, Barbara Parolini, Ahmed Sallam, Gianluca Besozzi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors genetic structures Fundus Oculi Visual Acuity Retinal Pigment Epithelium Transplantation Autologous Ophthalmology Humans Medicine Macula Lutea Fluorescein Angiography External limiting membrane Macular hole Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test Choroid business.industry Retinal detachment General Medicine Middle Aged Macular degeneration Fluorescein angiography medicine.disease eye diseases Angioid streaks Treatment Outcome medicine.anatomical_structure Wet Macular Degeneration Female sense organs Atrophy Epiretinal membrane business Microperimetry Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Retina. 40:507-520 |
| ISSN: | 0275-004X |
| Popis: | PURPOSE To evaluate the long-term results of autologous retinal pigment epithelium (RPE) and choroid transplantation (RPE-choroid patch) for exudative and atrophic maculopathies. METHODS Consecutive chart review of 120 eyes, which underwent RPE-choroid patch, from 2007 to 2017 for RPE atrophy or choroidal neovascular membrane secondary to exudative and hemorrhagic age-related macular degeneration, myopia, angioid streaks, and laser. Eyes were tested with best-corrected visual acuity (BCVA), reading ability, optical coherence tomography, fluorescein angiography and indocyanine green angiography, autofluorescence, and microperimetry. RESULTS Eighty-eight eyes of 84 patients had complete data, with 2- to 10-year follow-up. Mean age was 71.9 ± 9.06 years. Mean preoperative and postoperative BCVA was 20/320 (1.2 ± 0.2 logMAR) and 20/200 (0.94 ± 0.36 logMAR), respectively (P = 0.009). Reading ability recovered in 43% of cases. Microperimetry showed central fixation. A gain of at least 15 letters was obtained in 40% of eyes. Integrity (P = 0.009) of external limiting membrane and higher preoperative BCVA (P = 0.001) predicted better final BCVA. Complications were retinal detachment (11.4%), macular atrophy (7%), subretinal hemorrhage (4.5%), epiretinal membrane (4.5%), recurrent choroidal neovascular membrane (4.5%), macular hole (3.4%), and cystoid edema (3%). CONCLUSION Autologous RPE-choroid patch achieved long-lasting BCVA improvement and central fixation, in eyes with choroidal neovascular membrane and intact external limiting membrane. Atrophic maculopathies only obtained temporary visual benefit. |
| Databáze: | OpenAIRE |
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