Thymus: Conservation in evolution
| Autor: | Antonella Franchini, Enzo Ottaviani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Neuropeptide Thymus Gland Biology Adaptive Immunity Biological Evolution Neurosecretory Systems Cell biology 03 medical and health sciences 030104 developmental biology Endocrinology Immune system Apoptosis Immunity Immunology Fish Animals Humans Animal Science and Zoology Thymus POMC-derived peptides Apoptosis Evolution Hormone |
| Popis: | From an evolutionary point of view, the thymus is a new organ observed for the first time in fish concomitantly with the appearance of adaptive clonotypical immunity. Hormone and neuropeptide expression was demonstrated in different species suggesting a conserved role of these molecules. An integrated evolution of immune and neuroendocrine responses appears to have been realized by means of the re-use of ancestral material, such as neuroendocrine cells and mediators, to create a thymic microenvironment for the maturation and differentiation of T cells. |
| Databáze: | OpenAIRE |
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