Insomnia and Risk of Cardiovascular Disease

Autor: Sogol Javaheri, Susan Redline
Rok vydání: 2017
Předmět:
Pulmonary and Respiratory Medicine
Hypothalamo-Hypophyseal System
Sympathetic nervous system
medicine.medical_specialty
Pituitary-Adrenal System
Coronary Disease
Disease
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Risk Factors
law
Sleep Initiation and Maintenance Disorders
Internal medicine
mental disorders
medicine
Insomnia
Humans
cardiovascular diseases
Contemporary Reviews in Sleep Medicine
Heart Failure
Sleep disorder
business.industry
medicine.disease
Comorbidity
Observational Studies as Topic
C-Reactive Protein
medicine.anatomical_structure
Autonomic Nervous System Diseases
Cardiovascular Diseases
Heart failure
Hypertension
Cardiology
Physical therapy
Observational study
medicine.symptom
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Zdroj: Chest. 152:435-444
ISSN: 0012-3692
DOI: 10.1016/j.chest.2017.01.026
Popis: Insomnia is the most prevalent sleep disorder in the United States and has high comorbidity with a number of cardiovascular diseases (CVDs). In the past decade, a number of observational studies have demonstrated an association between insomnia and incident cardiovascular disease (CVD) morbidity and mortality, including hypertension (HTN), coronary heart disease (CHD), and heart failure (HF). Despite some inconsistencies in the literature, likely due to variations in how insomnia is defined and measured, the existing data suggest that insomnia, especially when accompanied by short sleep duration, is associated with increased risk for HTN, CHD and recurrent acute coronary syndrome, and HF. Purported mechanisms likely relate to dysregulation of the hypothalamic-pituitary axis, increased sympathetic nervous system activity, and increased inflammation. This paper reviews the most recent studies of insomnia and CVD and the potential pathophysiological mechanisms underlying this relationship and highlights the need for randomized trials to further elucidate the nature of the relationship between insomnia and CVD.
Databáze: OpenAIRE
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