Galactorrhea in a Patient With Aquaporin-4 Antibody-positive Neuromyelitis Optica Spectrum Disorder: A Case Report and Review of the Literature
| Autor: | Toshiyuki Takahashi, Masahiko Watanabe, Kentaro Furusho, Akira Tamaoka |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Galactorrhea medicine.medical_specialty Hypothalamus medicine Brain mri Humans Spectrum disorder Autoantibodies Aquaporin 4 Medulla Oblongata Neuromyelitis optica business.industry Neuromyelitis Optica Autoantibody General Medicine medicine.disease Dermatology Aquaporin-4 antibody Pituitary Gland Intracranial lesions Female Neurology (clinical) medicine.symptom business |
| Zdroj: | The neurologist. 20(6) |
| ISSN: | 2331-2637 |
| Popis: | This is the first report of a case of galactorrhea in a patient with neuromyelitis optica spectrum disorder (NMOSD) diagnosed on the basis of antiaquaporin-4 antibody seropositivity. The hypothalamus is becoming known as an area highly expressing aquaporin-4 and frequently involved in intracranial lesions of patients with neuromyelitis optica (NMO). We reviewed cases of hypothalamic endocrinopathy among patients with NMO, NMOSD, and the Japanese opticospinal form of MS. Among these cases, galactorrhea was the second most common symptom. Signs of hypothalamic endocrinopathies may be obscured by the grave neurological deficits caused by NMO. We recommend paying special attention to hypothalamic endocrinopathies among patients with NMO or NMOSD, irrespective of brain MRI findings. |
| Databáze: | OpenAIRE |
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