Effect of sodium tauroursodeoxycholate on phalloidin-induced cholestasis in rats
| Autor: | Kazuyuki Uchiyama, Minoru Maeda, Shigemasa Kinbara, Norio Hirabayashi, Kaoru Ishizaki |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Taurine medicine.drug_class Phalloidin Phalloidine macromolecular substances Cholestasis Intrahepatic Excretion Bile Acids and Salts Taurochenodeoxycholic Acid chemistry.chemical_compound Leucyl Aminopeptidase Cholestasis Internal medicine medicine Animals Bile Aspartate Aminotransferases Rats Wistar Biliary Tract Phospholipids Pharmacology Bile acid Dose-Response Relationship Drug Cholesterol Alanine Transaminase Bilirubin medicine.disease Alkaline Phosphatase Ursodeoxycholic acid Rats Endocrinology chemistry medicine.drug Waste disposal |
| Zdroj: | European journal of pharmacology. 421(1) |
| ISSN: | 0014-2999 |
| Popis: | We investigated the therapeutic effect of tauroursodeoxycholate on phalloidin-induced cholestasis in rats. Intrahepatic cholestasis was induced by administration of phalloidin (500 microg/kg, i.p.) for 7 days. From the day of the last phalloidin injection, tauroursodeoxycholate (60-360 micromol/kg) was given intravenously twice a day for 4 days. On the next day after the last tauroursodeoxycholate administration, bile flow, serum biochemical parameters and biliary lipid excretion rates were determined. Tauroursodeoxycholate significantly suppressed the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations observed in phalloidin-induced cholestasis in rats. Furthermore, tauroursodeoxycholate significantly improved the biliary cholesterol and phospholipid excretion rates in phalloidin-induced cholestasis in rats. These results demonstrate the usefulness of tauroursodeoxycholate as a therapeutic agent in intrahepatic cholestasis. |
| Databáze: | OpenAIRE |
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