Concurrent and prospective associations between HPA axis activity and depression symptoms in newlywed women

Autor: Paula R. Pietromonaco, Sally I. Powers, Casey J. DeBuse, Fiona Ge, Douglas A. Granger
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Hydrocortisone
Endocrinology
Diabetes and Metabolism
Pituitary-Adrenal System
050109 social psychology
Newlywed
Article
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Endocrinology
Dehydroepiandrosterone sulfate
Sex Factors
Internal medicine
medicine
Endocrine system
Humans
0501 psychology and cognitive sciences
Young adult
Marriage
Saliva
Biological Psychiatry
Depression (differential diagnoses)
Endocrine and Autonomic Systems
Dehydroepiandrosterone Sulfate
Depression
05 social sciences
Social environment
Middle Aged
Psychiatry and Mental health
medicine.anatomical_structure
chemistry
Female
Family Relations
Psychology
030217 neurology & neurosurgery
Hypothalamic–pituitary–adrenal axis
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Clinical psychology
Follow-Up Studies
Zdroj: Psychoneuroendocrinology. 73
ISSN: 1873-3360
Popis: We investigated the extent to which individual differences in activity of the hypothalamic pituitary adrenal axis (HPA) are associated with depressive symptoms among newlywed couples. Participants were 218 couples (M age 28.4 years; 94% White) who provided 5 saliva samples (later assayed for cortisol and DHEA-S) before and after participation in a discussion of a major area of disagreement in their relationship. Depressive symptoms were assessed initially, and approximately 19- and 37-months later. Results revealed an interactive effect suggesting that concordant levels of cortisol and DHEA-S (either both high or both low) were concurrently and prospectively associated with higher depression scores. Interestingly, this interactive effect was observed for wives only – not for husbands. These observations underscore contemporary theoretical assumptions that the expression of the association between HPA activity and depression is dependent on factors related to the interaction between characteristics of the person and features of the social environment, and moderated by co-occurring variation in endocrine milieu.
Databáze: OpenAIRE
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