Disability in progressive MS is associated with T2 lesion changes
| Autor: | Hartwig R. Siebner, Cecilie Ammitzbøll, J. Romme Christensen, Mark Lyksborg, Per Soelberg Sørensen, Pernille Iversen, Ellen Garde, Karen Schreiber, Rikke Ratzer, Tim B. Dyrby, Melinda Magyari, Finn Sellebjerg |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Multiple Sclerosis Magnetisation transfer ratio 030218 nuclear medicine & medical imaging Cohort Studies Lesion White matter Disability Evaluation 03 medical and health sciences 0302 clinical medicine Fractional anisotropy medicine Humans Gray Matter Expanded Disability Status Scale medicine.diagnostic_test business.industry Multiple sclerosis Brain Magnetic resonance imaging General Medicine Middle Aged Multiple Sclerosis Chronic Progressive medicine.disease White Matter Magnetic Resonance Imaging Cross-Sectional Studies Diffusion Tensor Imaging medicine.anatomical_structure Diffusion tensor imaging Neurology Multiple sclerosis functional composite Female Neurology (clinical) Radiology medicine.symptom business 030217 neurology & neurosurgery Diffusion MRI Expanded disability status scale |
| Zdroj: | Ammitzbøll, C, Dyrby, T B, Lyksborg, M, Schreiber, K, Ratzer, R, Christensen, J R, Iversen, P, Magyari, M, Garde, E, Sørensen, P S, Siebner, H R & Sellebjerg, F 2017, ' Disability in progressive MS is associated with T2 lesion changes ', Multiple Sclerosis and Related Disorders, vol. 20, pp. 73-77 . https://doi.org/10.1016/j.msard.2017.12.010 |
| Popis: | Background Progressive multiple sclerosis (MS) is characterised by diffuse changes on brain magnetic resonance imaging (MRI), which complicates the use of MRI as a diagnostic and prognostic marker. The relationship between MRI measures (conventional and non-conventional) and clinical disability in progressive MS therefore warrants further investigation. Objective To investigate the relationship between clinical disability and MRI measures in patients with progressive MS. Methods Data from 93 primary and secondary progressive MS patients who had participated in 3 phase 2 clinical trials were included in this cross-sectional study. From 3T MRI baseline scans we calculated total T2 lesion volume and analysed magnetisation transfer ratio (MTR) and the diffusion tensor imaging indices fractional anisotropy (FA) and mean diffusivity (MD) in T2 lesions, normal-appearing white matter (NAWM) and cortical grey matter. Disability was assessed by the Expanded Disability Status Scale (EDSS) and the MS functional composite. Results T2 lesion volume was associated with impairment by all clinical measures. MD and MTR in T2 lesions were significantly related to disability, and lower FA values correlated with worse hand function in NAWM. In multivariable analyses, increasing clinical disability was independently correlated with increasing T2 lesion volumes and MTR in T2 lesions. Conclusion In progressive MS, clinical disability is related to lesion volume and microstructure. |
| Databáze: | OpenAIRE |
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