Safety Assessment of Endocrine Disruption by Menopausal Health Functional Ingredients
| Autor: | Hagyeong Jo, So-Yeon Kang, Mee Ran Kim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
safety
Leadership and Management medicine.medical_treatment Physiology menopause Health Informatics Review functional food chemistry.chemical_compound Breast cancer Health Information Management Functional food Uterine cancer estrogen receptor alpha medicine Endocrine system phytoestrogens estrogen receptor beta Estrogen receptor binding business.industry Health Policy gynecology Hormone replacement therapy (menopause) medicine.disease Menopause endocrine disruptors chemistry Medicine Phytoestrogens business |
| Zdroj: | Healthcare Healthcare, Vol 9, Iss 1376, p 1376 (2021) |
| ISSN: | 2227-9032 |
| Popis: | During menopause, women experience various symptoms including hot flashes, mood changes, insomnia, and sweating. Hormone replacement therapy (HRT) has been used as the main treatment for menopausal symptoms; however, other options are required for women with medical contraindications or without preference for HRT. Functional health foods are easily available options for relieving menopausal symptoms. There are growing concerns regarding menopausal functional health foods because the majority of them include phytoestrogens which have the effect of endocrine disruption. Phytoestrogens may cause not only hormonal imbalance or disruption of the normal biological function of the organ systems, but also uterine cancer or breast cancer if absorbed and accumulated in the body for a long period of time, depending on the estrogen receptor binding capacity. Therefore, we aimed to determine the effects and safety of menopausal functional health ingredients and medicines on the human body as endocrine disruptors under review in the literature and the OECD guidelines. |
| Databáze: | OpenAIRE |
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