The functions of Wt1 in mouse gonad development and somatic cells differentiation†
| Autor: | Min Chen, Changhuo Cen, Nan Wang, Zhiming Shen, Mengyue Wang, Bowen Liu, Jiayi Li, Xiuhong Cui, Yanbo Wang, Fei Gao |
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| Rok vydání: | 2021 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities endocrine system Genes Wilms Tumor urogenital system Cell Differentiation Cell Biology General Medicine urologic and male genital diseases female genital diseases and pregnancy complications Mice Reproductive Medicine Animals Humans Female Gonads WT1 Proteins |
| Zdroj: | Biology of reproduction. 107(1) |
| ISSN: | 1529-7268 |
| Popis: | Wilms’ tumor 1 (Wt1) encodes a zinc finger nuclear transcription factor which is mutated in 15–20% of Wilms’ tumor, a pediatric kidney tumor. Wt1 has been found to be involved in the development of many organs. In gonads, Wt1 is expressed in genital ridge somatic cells before sex determination, and its expression is maintained in Sertoli cells and granulosa cells after sex determination. It has been demonstrated that Wt1 is required for the survival of the genital ridge cells. Homozygous mutation of Wt1 causes gonad agenesis. Recent studies find that Wt1 plays important roles in lineage specification and maintenance of gonad somatic cells. In this review, we will summarize the recent research works about Wt1 in gonadal somatic cell differentiation. |
| Databáze: | OpenAIRE |
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