Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis
| Autor: | Devon S. Conway, Paola Saroufim, Sophia Alison Zweig, Farren B.S. Briggs |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Heart disease Population Myelitis Transverse Transverse myelitis 03 medical and health sciences 0302 clinical medicine Internal medicine Demyelinating disease Prevalence Medicine Humans 030212 general & internal medicine Family history Age of Onset education Aged education.field_of_study Neuromyelitis optica business.industry Multiple sclerosis Neuromyelitis Optica General Medicine Middle Aged medicine.disease Logistic Models Neurology Cardiovascular Diseases Case-Control Studies Female Neurology (clinical) Age of onset business 030217 neurology & neurosurgery |
| Zdroj: | Multiple sclerosis and related disorders. 25 |
| ISSN: | 2211-0356 |
| Popis: | Background Cardiovascular conditions are associated with poorer outcomes in multiple sclerosis (MS). Whether the burden of cardiovascular conditions differs between those with demyelinating disease and unaffected controls is not clear. The objective of this study is to investigate the burden and age of onset of cardiovascular conditions in a US population with MS, neuromyelitis optica spectrum disorder (NMOSD), or transverse myelitis (TM) to unaffected controls adjusting for likely confounders. Methods Using a case-control study design, we compared the burden of self-reported diabetes mellitus type 2, heart disease, hyperlipidemia, and hypertension in cases with MS (N = 1,548), NMOSD (N = 306), and TM (N = 145) to controls (N = 677), adjusting for demographics, smoking history, obesity, family history of individual cardiovascular conditions, and presence of other cardiovascular conditions. The age of onset for individual cardiovascular conditions were also compared between cases and controls. Results MS cases were 48% more likely to have ever had hypertension than controls (p = 0.01). The prevalence of other cardiovascular conditions did not differ across cases and controls. There were also no differences in the age of cardiovascular disease onset between cases and controls. Conclusion Cardiovascular conditions are as common in those with demyelinating diseases compared to unaffected individuals, with hypertension being more common among those with MS. |
| Databáze: | OpenAIRE |
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