Relation between change in exercise capacity and change in blood amino acids in patients with chronic heart failure
| Autor: | Masakazu Saitoh, Kayoko Ohno, Nobuyuki Kawate, Noriko Ishii, Masazumi Mizuma, Masatoshi Nagayama, Nobuo Morotomi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Physical Therapy Sports Therapy and Rehabilitation 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Citrulline Exercise capacity In patient chemistry.chemical_classification business.industry VO2 max Plasma levels medicine.disease Chronic heart failure Amino acid chemistry Heart failure Cardiology Original Article business Anaerobic exercise 030217 neurology & neurosurgery |
| Zdroj: | Journal of Physical Therapy Science |
| ISSN: | 2187-5626 0915-5287 |
| Popis: | [Purpose] Although cardiac rehabilitation (CR) is recommended for patients with chronic heart failure (CHF), adequate exercise effect cannot be obtained in elderly patients. Administration of amino acids (AA) to CHF patients has been reported to improve exercise capacity, but the changes in AA composition in plasma before and after CR had not been reported. This study aimed to measure plasma levels of AA in CHF patients and compare with values of normal range. In addition the relationship between the change of exercise capacity and AA were examined. [Subjects and Methods] Twelve CHF patients (60% males, aged 68 ± 12 years) were studied. The correction between the rates of changes in exercise capacity parameters and in plasma AA levels was investigated. [Results] Anaerobic threshold (AT) and peak oxygen uptake (VO2) improved significantly after CR. The AA profile showed no specific pattern, and citrulline (Cit) was the amino acid showing a significant positive correlation with exercise capacity (∆Cit vs. ∆AT: r=0.602, ∆Cit vs. ∆AT-work rate (WR): r=0.681, ∆Cit vs. ∆VO2/WR: r=0.635). A tendency of positive correlation was observed between ∆Cit and ∆peak VO2 (r=0.456). [Conclusion] The AA profile showed no specific pattern, but a relationship between change in exercise capacity and Cit were found. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|