Interleukins and inflammatory markers are useful in predicting the severity of acute pancreatitis

Autor: Milan Zorman, Pavel Skok, Davorin Ćeranić
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Blood Glucose
Male
Gastroenterology
Severity of Illness Index
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Aged
80 and over
lcsh:R5-920
Interleukin
General Medicine
Gallstones
Middle Aged
inflammatory markers
030220 oncology & carcinogenesis
Ranson’s criteria
Acute pancreatitis
030211 gastroenterology & hepatology
Female
Inflammation Mediators
lcsh:Medicine (General)
Area under the roc curve
Alcohol consumption
Research Article
Adult
medicine.medical_specialty
etiology
scoring systems
03 medical and health sciences
Young Adult
Predictive Value of Tests
Internal medicine
Lactate dehydrogenase
medicine
Humans
Aged
Receiver operating characteristic
L-Lactate Dehydrogenase
business.industry
Platelet Count
Interleukins
medicine.disease
IL6
chemistry
Pancreatitis
ROC Curve
Etiology
business
Biomarkers
Zdroj: Bosnian Journal of Basic Medical Sciences
Bosnian Journal of Basic Medical Sciences (2019)
ISSN: 1840-4812
1512-8601
Popis: Acute pancreatitis (AP) is a disease with significant morbidity and mortality. The aim of this study was to evaluate the prognostic role of inflammatory markers, particularly interleukins (ILs), in the course of AP and to determine the frequency of etiologic factors of AP. We included patients with AP who were treated at our institution from May 1, 2012 to January 31, 2015. Different laboratory parameters, including ILs, and the severity scoring systems Ranson’s criteria and Bedside Index of Severity in Acute Pancreatitis (BISAP) were analyzed. AP was classified into mild and severe, and independent parameters were compared between these groups. The predictive performance of each parameter was evaluated using receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC). A binomial logistic regression was performed to evaluate Ranson’s criteria and IL6, IL8, and IL10 (at admission and after 48 hours) in the course of AP. Overall, 96 patients were treated, 59 (61.5%) males and 37 (38.5%) females, average age 62.5 ± 16.8 years (range 22–91 years). The best predictor for the severity of AP was IL6, measured 48 hours after admission (AUC = 0.84). Other useful predictors of the severity of AP were lactate dehydrogenase (p < 0.001), serum glucose (p < 0.006), and difference in the platelet count (p < 0.001) between admission and after 48 hours (p < 0.001), hemoglobin (p < 0.027) and erythrocytes (p < 0.029). The major causes of AP were gallstones and alcohol consumption. According to our results, IL6 and Ranson score are important predictors of the severity of AP.
Databáze: OpenAIRE
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