Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
| Autor: | Meng-Yuan Tsai, Chia-Ling Chiang, Bao-Hui Hung, Huay-Ben Pan, Tsung-Lung Yang, Jer-Shyung Huang, Chen-Pin Chou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Contrast Media
Diagnostic Radiology Breast Tumors Medicine and Health Sciences Medicine Multidisciplinary medicine.diagnostic_test Radiology and Imaging Ultrasound Washout Middle Aged Magnetic Resonance Imaging Oncology Female Benign Breast Conditions Ultrasonography Mammary medicine.symptom Research Article Mammography Adult Computer and Information Sciences Imaging Techniques Science Breast Neoplasms Digital Imaging Research and Analysis Methods Sensitivity and Specificity Lesion Breast cancer Text mining Signs and Symptoms Malignant Tumors Diagnostic Medicine Breast Cancer Cancer Detection and Diagnosis Humans Receiver operating characteristic business.industry Cancers and Neoplasms Magnetic resonance imaging medicine.disease Lesions Women's Health Clinical Medicine business Nuclear medicine |
| Zdroj: | PLoS ONE, Vol 15, Iss 9, p e0239271 (2020) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | PurposeTo evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM).MethodsWomen with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired at 2, 3, 4, 7, and 10 min after injection of contrast agent. Three readers visually and semi-quantitatively analyzed the enhancement of suspicious lesions. The kinetic pattern of each lesion was classified as persistent, plateau, or washout over two time intervals, 2-4 min and 2-10 min, by comparing the signal intensity at the first time interval with that at the second.ResultsThere were 73 malignant and 75 benign lesions in 148 patients (mean age: 52 years). Benign and malignant breast lesions showed the highest signal intensity at 3 min and 2 min, respectively. Average areas under receiver operating characteristic (ROC) curve for diagnostic accuracy based on lesion enhancement at different time points were 0.73 at 2 min, 0.72 at 3 min, 0.69 at 4 min, 0.67 at 7 min, and 0.64 at 10 min. Diagnostic performance was significantly better at 2, 3, and 4 min than at 7 and 10 min (all p < 0.05). A washout kinetic pattern was significantly associated with malignant lesions at 2-4 min and 2-10 min frames according to two of the three readers' interpretations (all p ≤ 0.001).ConclusionApplications of optimal time intervals and kinetic patterns show promise in differentiation of benign and malignant breast lesions on CEDM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|