| Autor: |
Joshua D. Shamblin, Wen Li, Kathleen B. J. Pommert, Mark S. Klempner, Ashley E. Piper, Thomas R. Sprague, Pamela J. Glass, Arthur J. Goff, Colby A. Souders, Keith A. Reimann, Andrew B. Ward, Laura M. Walker, Karl Dane Wittrup, Erica Ollmann Saphire, Dennis R. Burton, Heidi L. Smith, Charles D. Murin, Eric Krauland, Tillman U. Gerngross, Suzanne E. Wollen, Lisa A. Cavacini, Devin Sok, Hannah L. Turner, Marnie L. Fusco, Zachary A. Bornholdt |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Science. 351:1078-1083 |
| ISSN: |
1095-9203
0036-8075 |
| Popis: |
Profiling the antibody response to Ebola The recent Ebola virus outbreak in West Africa illustrates the need not only for a vaccine but for potential therapies, too. One promising therapy is monoclonal antibodies that target Ebola's membrane-anchored glycoprotein (GP). Bornholdt et al. isolated and characterized 349 antibodies from a survivor of the 2014 outbreak. A large fraction showed some neutralizing activity and several were quite potent. Structural analysis revealed an important site of vulnerability on the membrane stalk region of GP. Antibodies targeting this area were therapeutically effective in Ebola virus–infected mice. Science , this issue p. 1078 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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