PLTP regulates STAT3 and NFκB in differentiated THP1 cells and human monocyte-derived macrophages
| Autor: | Weijiang Dong, Simona Vuletic, Chongren Tang, John J. Albers, Gertrud Wolfbauer |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
STAT3 Transcription Factor
Human monocyte-derived macrophage Inflammation Biology Article Interferon-gamma Differentiated THP1 cell STAT3 activation Cell Line Tumor Phospholipid transfer protein Glyburide medicine Humans Hypoglycemic Agents Interferon gamma Secretion Phospholipid Transfer Proteins STAT3 Molecular Biology Phospholipids Cell Nucleus Leukemia Tumor Necrosis Factor-alpha Macrophages NF-kappa B Biological Transport Cell Differentiation Cell Biology NFKB1 Cell biology NFκB reduction Biochemistry STAT protein biology.protein ATP-Binding Cassette Transporters Tumor necrosis factor alpha medicine.symptom ATP Binding Cassette Transporter 1 medicine.drug |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813(10):1917-1924 |
| ISSN: | 0167-4889 |
| DOI: | 10.1016/j.bbamcr.2011.06.013 |
| Popis: | Phospholipid transfer protein (PLTP) plays an important role in regulation of inflammation. Previously published studies have shown that PLTP binds, transfers and neutralizes bacterial lipopolysaccharides. In the current study we tested the hypothesis that PLTP can also regulate anti-inflammatory pathways in macrophages. Incubation of macrophage-like differentiated THP1 cells and human monocyte-derived macrophages with wild-type PLTP in the presence or absence of tumor necrosis factor alpha (TNFα) or interferon gamma (IFNγ) significantly increased nuclear levels of active signal transducer and activator of transcription 3, pSTAT3Tyr705 (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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