Regulation of FSH receptor promoter activation in the osteoclast
| Autor: | Rajesh Mali, Samir Zaidi, Ling-Ling Zhu, Guozhe Yang, Jameel Iqbal, Mone Zaidi, Li Sun |
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| Rok vydání: | 2007 |
| Předmět: |
Transcriptional Activation
endocrine system medicine.medical_specialty medicine.drug_class medicine.medical_treatment Molecular Sequence Data Biophysics Osteoclasts Biochemistry Cell Line Mice Genes Reporter Osteoclast Internal medicine Consensus Sequence Follicular phase medicine Animals Luciferases Promoter Regions Genetic Receptor Molecular Biology Base Sequence Activator (genetics) Chemistry Stem Cells Cell Biology medicine.anatomical_structure Endocrinology Cytokine Cell culture Estrogen Receptors FSH Follicle-stimulating hormone receptor hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochemical and Biophysical Research Communications. 361:910-915 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2007.07.081 |
| Popis: | We have shown recently that FSH stimulates osteoclast formation and function by a direct action on a G(i)-coupled FSH receptor (FSHR). Here, we report properties of the mouse FSH receptor promoter in the context of its activation in RAW-C3 osteoclast precursor macrophages. Basal promoter activity was low, but was significantly stimulated by receptor activator for NF-kappaB-ligand (RANK-L), a critical osteoclastogenic and pro-resorptive cytokine. In contrast, FSH dampened FSHR promoter activation, while estrogen had no effect. We surmise that the FSHR expression is regulated distinctly in the osteoclast, and differently from other cells, such as the ovarian follicular and Leydig cells. |
| Databáze: | OpenAIRE |
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