State-dependent reductions of local brain connectivity in schizophrenia and their relation to performance and symptoms: A functional magnetic resonance imaging study
| Autor: | Stefano Damiani, Livio Tarchi, Paolo La-Torraca-Vittori, Andrea Scalabrini, Giovanni Castellini, Valdo Ricca, Paolo Fusar-Poli, Pierluigi Politi |
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| Rok vydání: | 2022 |
| Předmět: |
fMRI
Schizophrenia spectrum Regional homogeneity Functional connectivity Neuroimaging Psychiatry and Mental health Settore M-PSI/02 - Psicobiologia e Psicologia Fisiologica Settore M-PSI/07 - Psicologia Dinamica Neuroscience (miscellaneous) Radiology Nuclear Medicine and imaging Settore MED/25 - Psichiatria |
| Zdroj: | Psychiatry research. Neuroimaging. 326 |
| ISSN: | 1872-7506 |
| Popis: | State-dependent reallocation of cognitive resources is impaired in schizophrenia and may be underlined by alterations in brain local-connectivity. Increasing evidence suggests local connectivity reductions from rest to task in healthy individuals, while insufficient information is available for schizophrenia spectrum. Resting-state and stop-signal task fMRI scans of 107 healthy controls and 32 patients with DSM-IV-TR schizophrenia or schizoaffective disorder were analyzed. As primary aim we measured within-group shifts in local-connectivity from rest to task as voxel-wise Regional Homogeneity (ReHo-shift). Secondary aims were to test: i) Between-groups differences in ReHo-rest, ReHo-task and ReHo-shift; ii) ReHo covariations with task performance (=shorter reaction times) and severity of symptoms (SAPS/SANS scores). Age, sex, and education were accounted for as covariates. Motion, global-signal-regression, antipsychotic dosage and smoothing associations with ReHo were evaluated. Rest-to-task ReHo reductions occurred in both groups on a whole-brain level (False-Discovery-Rate p=0.05). Trends of greater ReHo reductions in patients versus controls were observed. Controls performed better than patients (p0.001). ReHo negatively correlated with performance in both groups. ReHo-shift predicted worse performance in controls, but better performance in patients (uncorrected p=0.05). ReHo reductions correlated with severity of symptoms. State-dependent reconfigurations in local-connectivity provide new links between neurobiology and behavioral/clinical features of the schizophrenia spectrum. |
| Databáze: | OpenAIRE |
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