Increased ventilation and CO2 chemosensitivity in acetylcholinesterase knockout mice
| Autor: | Eliane Boudinot, Jean Champagnat, Arnaud Chatonnet, Pierre Escourrou, M. J. Emery, Etienne Mouisel, Arthur S. Foutz |
|---|---|
| Přispěvatelé: | Neurobiologie génétique et intégrative (NGI), Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Sérotonine et neuropharmacologie, Université Paris-Sud - Paris 11 (UP11)-IFR141, Département de Physiologie Animale, Institut National de la Recherche Agronomique (INRA), IFR141-Université Paris-Sud - Paris 11 (UP11), Département de Physiologie Animale (PA), Différenciation Cellulaire et Croissance (DCC), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2), ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Aging
Mouse Physiology [SDV]Life Sciences [q-bio] MESH: Anoxia MESH: Carbon Dioxide MESH: Pulmonary Ventilation Gene MESH: Mice Knockout Hypercapnia Mice 0302 clinical medicine MESH: Aging MESH: Animals MESH: Oxygen Consumption Respiratory system Hypoxia ComputingMilieux_MISCELLANEOUS Mice Knockout Mammals 0303 health sciences Respiration General Neuroscience SOURIS KNOCKOUT Adaptation Physiological [SDV] Life Sciences [q-bio] Acetylcholinesterase Breathing MESH: Respiratory Mechanics Female CO2 [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] medicine.symptom Pulmonary and Respiratory Medicine medicine.medical_specialty Control of breathing Respiratory rate [INFO] Computer Science [cs] Biology AChE knockout 03 medical and health sciences Oxygen Consumption Internal medicine MESH: Analysis of Variance Hyperventilation medicine Animals [INFO]Computer Science [cs] Chemosensitivity MESH: Mice 030304 developmental biology MESH: Respiration Analysis of Variance Acetylcholinesterase knockout Carbon Dioxide Hypoxia (medical) MESH: Acetylcholinesterase MESH: Adaptation Physiological Endocrinology Control of respiration Enzyme MESH: Hypercapnia Respiratory Mechanics AChE Pulmonary Ventilation MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Respiratory Physiology and Neurobiology Respiratory Physiology and Neurobiology, Elsevier, 2004, 140 (3), pp.231-41. ⟨10.1016/j.resp.2004.03.002⟩ Respiratory Physiology and Neurobiology, Elsevier, 2004, 140, pp.231-241 |
| ISSN: | 1569-9048 1878-1519 |
| DOI: | 10.1016/j.resp.2004.03.002⟩ |
| Popis: | To investigate the effects of a permanent excess of acetylcholine (AChE) on respiration, breathing and chemosensitivity were analyzed from birth to adulthood in mice lacking the AChE gene (AChE-/-), in heterozygotes, and in control wild-type (AChE+/+) littermates. Breathing at rest and ventilatory responses to brief exposures to hypoxia (10% O2) and hypercapnia (3-5% CO2) were measured by whole-body plethysmography. At rest AChE-/- mice show larger tidal volumes (VT, + 96% in adults), overall ventilation (VE, + 70%), and mean inspiratory flow (+270%) than wild-type mice, with no change in breathing frequency (fR). AChE-/- mice have a slightly blunted response to hypoxia, but increased VE and fR responses to hypercapnia. Heterozygous animals present no consistent alterations of breathing at rest and chemosensitivity is normal. Adult AChE-/- mice have an increased VE/VO2 and a marginally higher normalized VO2. The results suggest that the hyperventilation and altered chemosensitivity in AChE-/- mice largely reflect alterations of central respiratory control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect