Early and Long-term Undernutrition in Female Rats Exacerbates the Metabolic Risk Associated with Nutritional Rehabilitation
| Autor: | Elisa Fernández-Millán, Manuel Ros, Juan de Toro-Martín, Carmen Álvarez, Teresa Fernández-Agulló, Miriam García-San Frutos, F. Escrivá, Esther Lizárraga-Mollinedo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Leptin
Male Pro-Opiomelanocortin Overweight Biochemistry Pregnancy Risk Factors Pro-Opiomelanocortin -- metabolism Neuropeptide Y hypothalamus Adiposity biology Prenatal Exposure Delayed Effects -- etiology -- metabolism Molecular Bases of Disease Sciences bio-médicales et agricoles Diet High-Fat -- adverse effects Muscle Skeletal -- metabolism -- pathology adipose tissue nutrition Liver Prenatal Exposure Delayed Effects Female Hypothalamus -- metabolism medicine.symptom Oxidation-Reduction insulin medicine.medical_specialty Adipose Tissue White Hypothalamus Cafeteria Hyperphagia Diet High-Fat leptin Insulin resistance Internal medicine medicine Animals Adipose Tissue White -- metabolism -- pathology Obesity Rats Wistar Muscle Skeletal Molecular Biology Neuropeptide Y -- metabolism business.industry Malnutrition Liver -- metabolism -- pathology Obesity -- etiology -- metabolism Cell Biology biology.organism_classification medicine.disease Hyperphagia -- etiology -- metabolism undernutrition Endocrinology Lean body mass Leptin -- metabolism Insulin Resistance business Energy Intake Malnutrition -- complications -- metabolism -- rehabilitation Body mass index Dyslipidemia |
| Zdroj: | The Journal of biological chemistry, 290 (31 |
| ISSN: | 1083-351X |
| Popis: | Human studies have suggested that early undernutrition increases the risk of obesity, thereby explaining the increase in overweight among individuals from developing countries who have been undernourished as children. However, this conclusion is controversial, given that other studies do not concur. This study sought to determine whether rehabilitation after undernutrition increases the risk of obesity and metabolic disorders. We employed a published experimental food-restriction model. Wistar female rats subjected to severe food restriction since fetal stage and controls were transferred to a moderately high-fat diet (cafeteria) provided at 70 days of life to 6.5 months. Another group of undernourished rats were rehabilitated with chow. The energy intake of undernourished animals transferred to cafeteria formula exceeded that of the controls under this regime and was probably driven by hypothalamic disorders in insulin and leptin signal transduction. The cafeteria diet resulted in greater relative increases in both fat and lean body mass in the undernourished rats when compared with controls, enabling the former group to completely catch up in length and body mass index. White adipose tissues of undernourished rats transferred to the high-lipid regime developed a browning which, probably, contributed to avoid the obesigenic effect observed in controls. Nevertheless, the restricted group rehabilitated with cafeteria formula had greater accretion of visceral than subcutaneous fat, showed increased signs of macrophage infiltration and inflammation in visceral pad, dyslipidemia, and ectopic fat accumulation. The data indicate that early long-term undernutrition is associated with increased susceptibility to the harmful effects of nutritional rehabilitation, without causing obesity. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|