Combination of specific allergen and probiotics induces specific regulatory B cells and enhances specific immunotherapy effect on allergic rhinitis
| Autor: | Xiao-Rui Geng, Ling-Zhi Xu, Zhong Wen, Shuai Wang, Huabin Li, Jun Liu, Li-Tao Yang, Ping-Chang Yang, Zhigang Liu, Xiang-Qian Luo, Bei-Ping Miao, Huan-Ping Zhang, Gui Yang, Shu-Qi Qiu, Jing Li, Zhi-Qiang Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Regulatory B cells medicine.medical_treatment B-cell receptor Butyrate Immunoglobulin E medicine.disease_cause 03 medical and health sciences Allergen Immune system Antigen medicine Humans Immune response B-Lymphocytes Regulatory allergic rhinitis biology business.industry Probiotics Research Paper: Immunology Immunity Cell Differentiation regulatory B cells Rhinitis Allergic Interleukin-10 Butyrates 030104 developmental biology Cytokine Oncology Desensitization Immunologic Immunology biology.protein Clostridium butyricum Immunology and Microbiology Section Female business specific immunotherapy |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | The therapeutic efficacy of allergen specific immunotherapy (SIT) on allergic diseases is to be improved. Probiotics can regulate immune response. This study aims to promote the effect of SIT on allergic rhinitis (AR) by co-administration with Clostridium butyricum (Cb). In this study, patients with AR sensitized to mite allergens were enrolled to this study, and treated with SIT or/and Cb. The therapeutic efficacy was evaluated by the total nasal symptom scores (NSS), medication scores, serum specific IgE levels and T helper (Th)2 cytokine levels. The improvement of immune regulation in the AR patients was assessed by immunologic approaches. The results showed that treating AR patients with SIT alone markedly reduced NSS and medication scores; but did not alter the serum specific IgE, Th2 cytokines and skin prick test (SPT) index. The clinical symptoms on AR in SIT group relapsed one month after stopping SIT. Co-administration of Cb significantly enhanced the efficacy of SIT on AR as shown by suppression of NSS, medication scores, serum specific IgE, Th2 cytokines and SPT index; the regulatory B cell frequency was also markedly increased. Such an effect on AR was maintained throughout the observation period even after stopping the treatment. Butyrate blocked the activation of histone deacetylase-1, the downstream activities of epsilon chain promoter activation, and the IgE production in the antigen specific B cells. On the other hand, butyrate induced the IL-10 expression in B cells with a premise of the B cell receptor activation by specific antigens. In conclusion, administration with Cb can markedly enhance the efficacy of SIT on AR. |
| Databáze: | OpenAIRE |
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