Immunotherapy with Stimulated Autologous Lymphocytes in a Case of a Juvenile Anaplastic Glioma*
| Autor: | D B Jacques, C B Lumenta, W. Wechsler, H. G. Lenard, C. Thomas, R Schober |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Interleukin 2
Pathology medicine.medical_specialty Necrosis medicine.medical_treatment Lymphocyte Activation Immunotherapy Adoptive In vivo Glioma medicine Humans Killer Cells Lymphokine-Activated Cerebral Cortex Brain Neoplasms business.industry General Medicine Immunotherapy T lymphocyte medicine.disease Combined Modality Therapy Tumor progression Child Preschool Pediatrics Perinatology and Child Health Interleukin-2 Female Neurology (clinical) Neoplasm Recurrence Local medicine.symptom business Anaplastic astrocytoma medicine.drug |
| Zdroj: | Neuropediatrics. 23:123-125 |
| ISSN: | 1439-1899 0174-304X |
| DOI: | 10.1055/s-2008-1071326 |
| Popis: | The effect of immunotherapy with stimulated autologous lymphocytes (SAL) in malignant gliomas is documented and discussed in a bioptical and autoptical case study. A five-year-old child with a recurrently operated and radiated right hemispheric anaplastic astrocytoma died six weeks after immunotherapy with mitogen-activated killer cells and recombinant Interleukin-2. The autopsy revealed a large butterfly glioma with partially necrotic gelatinous tissue at the site of the SAL reservoir. The tumor cell density on the right was less than on the left hemisphere, and T-lymphocyte content was higher on the right hemisphere. These results demonstrate a local effect of SAL therapy in vivo, although the tumor progression as a whole could not be stopped. They also demonstrate the need of a detailed neuropathological examination in all cases of immunotherapy of malignant gliomas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|