A Multidisciplinary Approach to Coronavirus Disease (COVID-19)

Autor: Sirin Oba Ilter, Ebru Bati Ay, Arzu Sahin, Aliye Gediz Erturk, Emel Pelit, Seda Mesci, Tuba Yildirim, Emine Bagdatli, Irem Kulu, Melek Gul, Serpil Eryılmaz
Rok vydání: 2021
Předmět:
Drug
COVID-19 Vaccines
natural products
media_common.quotation_subject
medicine.medical_treatment
small drugs
Pharmaceutical Science
Organic chemistry
Review
Computational biology
Disease
medicine.disease_cause
Antiviral Agents
Analytical Chemistry
dietary supplements
03 medical and health sciences
0302 clinical medicine
QD241-441
Functional food
Drug Discovery
medicine
Humans
Physical and Theoretical Chemistry
Repurposing
030304 developmental biology
media_common
Coronavirus
0303 health sciences
Biological Products
business.industry
SARS-CoV-2
Drug Repositioning
COVID-19
repurposing drugs
Immunotherapy
Food safety
Drug repositioning
vaccine development
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
Drug Design
cytokine storm
in-silico research
Molecular Medicine
business
Cytokine Release Syndrome
Zdroj: Molecules, Vol 26, Iss 3526, p 3526 (2021)
Molecules
ISSN: 1420-3049
Popis: Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the world has been to direct their time to research this subject. In this review, we highlight chemical studies and therapeutic approaches to overcome COVID-19 with seven different sections. These sections are the structure and mechanism of action of SARS-CoV-2, immunotherapy and vaccine, computer-aided drug design, repurposing therapeutics for COVID-19, synthesis of new molecular structures against COVID-19, food safety/security and functional food components, and potential natural products against COVID-19. In this work, we aimed to screen all the newly synthesized compounds, repurposing chemicals covering antiviral, anti-inflammatory, antibacterial, antiparasitic, anticancer, antipsychotic, and antihistamine compounds against COVID-19. We also highlight computer-aided approaches to develop an anti-COVID-19 molecule. We explain that some phytochemicals and dietary supplements have been identified as antiviral bioproducts, which have almost been successfully tested against COVID-19. In addition, we present immunotherapy types, targets, immunotherapy and inflammation/mutations of the virus, immune response, and vaccine issues.
Databáze: OpenAIRE
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