Tumor location as an indication for adjuvant radiotherapy in pT3N0 rectal cancer after surgery

Autor: Xing-sheng Qiu, Tong-Chong Zhou, Xin-hui Zhou, Hai-hua Peng, Kai-yun You
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
lcsh:R895-920
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
medicine
Adjuvant therapy
Humans
Chemotherapy
Radiology
Nuclear Medicine and imaging
Tumor location
Rectal cancer
Neoplasm Staging
Retrospective Studies
Adjuvant radiotherapy
Radiotherapy
Rectal Neoplasms
business.industry
Research
Retrospective cohort study
Chemoradiotherapy
Adjuvant
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Combined Modality Therapy
Neoadjuvant Therapy
Surgery
Survival Rate
Radiation therapy
Oncology
030220 oncology & carcinogenesis
Female
Radiotherapy
Adjuvant
Neoplasm Recurrence
Local
business
Adjuvant
Follow-Up Studies
Zdroj: Radiation Oncology, Vol 14, Iss 1, Pp 1-8 (2019)
Radiation Oncology (London, England)
DOI: 10.1186/s13014-019-1206-3
Popis: Background The optimal care for pT3N0 rectal cancer remains controversial. And whether tumor location can be used to guide the administration of adjuvant radiotherapy for pT3N0 rectal cancer is not fully confirmed. The current study was designed to identify the benefit of adjuvant radiotherapy for pT3N0 rectal cancer. Methods We performed a retrospective study of 265 pT3N0 rectal cancer patients who were treated by surgery and adjuvant therapy from Mar. 2005 to Sept. 2015. All patients were divided into two groups according to receiving adjuvant radiotherapy or not. Overall survival (OS), disease-free survival (DFS) were compare between patients who did and did not receive adjuvant radiotherapy. Multivariate analysis was performed to explore clinical factors significantly associated with DFS, local recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS). Results For patients with lower tumor, DFS in adjuvant chemo-radiotherapy group was higher than that in adjuvant chemotherapy group. Besides, the rates of local recurrence and distant metastasis were found lower in patients who did receive adjuvant radiotherapy than those who did not. For patients with upper tumor, the 5-year OS and DFS were similar between groups of adjuvant chemotherapy and adjuvant chemo-radiotherapy. Multivariable analysis indicated both the CEA and tumor location were independent predictors of LRFS. And adjuvant radiotherapy predicted the DFS, LRFS and DMFS in lower rectal cancer patients. Conclusion Tumor location can serve as an indication for the administration of adjuvant radiotherapy in pT3N0 rectal cancer patients.
Databáze: OpenAIRE
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