A deficit of brain dystrophin 71 impairs hypothalamic osmostat

Autor: Danièle Raison, Alvaro Rendon, Ouahiba Benmessaoud-Mesbah, Roza Benabdesselam, Latifa Dorbani-Mamine, Dominique Mornet, Abdoulaye Sene, David Yaffe, Ghazi Ayad, Hélène Hardin-Pouzet
Přispěvatelé: Equipe de Neurochimie (LBPO), Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurobiologie des signaux intercellulaires (NSI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Muscle et pathologies, Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Department of Molecular Cell Biology [Rehovot], Weizmann Institute of Science [Rehovot, Israël], Université des Sciences et de la Technologie Houari Boumediene = University of Sciences and Technology Houari Boumediene [Alger] (USTHB), Passerieux, Emilie
Rok vydání: 2010
Předmět:
Male
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Vasopressin
Vasopressins
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
vasopressin
Duchenne muscular dystrophy
Hypothalamus
Supraoptic nucleus
Dystrophin
Mice
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Pituitary Gland
Posterior
Internal medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
medicine
Animals
RNA
Messenger
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Mice
Knockout
Mice
Inbred BALB C
0303 health sciences
biology
Brain
Water
Water-Electrolyte Balance
medicine.disease
Pituicyte
Plasma osmolality
Blood
Endocrinology
medicine.anatomical_structure
biology.protein
Osmoregulation
supraoptic nucleus
Salts
osmoregulation
neurohypophy- sis
Dp71
030217 neurology & neurosurgery
Astrocyte
Zdroj: Journal of Neuroscience Research
Journal of Neuroscience Research, Wiley, 2010, ⟨10.1002/jnr.22198⟩
Journal of Neuroscience Research, 2010, ⟨10.1002/jnr.22198⟩
ISSN: 1097-4547
0360-4012
DOI: 10.1002/jnr.22198
Popis: Patients with Duchenne muscular dystrophy (DMD) and mdx mice, devoid of dystrophin proteins, show altered ionic homeostasis. To clarify dystrophin's involvement in the central control of osmotic stimuli, we investigated the effect of the disruption of Dp71, the major form of dystrophin in the brain, on the hypothalamoneurohypophysis system (HNHS) osmoregulatory response. Dp71 and Dp140 are the principal DMD gene products in the supraoptic nucleus (SON) and neurohypophysis (NH). They are present in astrocyte and pituicyte end-feet, suggesting involvement in both intrinsic osmosensitivity of the SON and vasopressin (AVP) release from the NH. In Dp71-null mice, the cellular distribution of Dp140 was modified, this protein being detected on the membrane of magnocellular soma. The plasma osmolality of Dp71-null mice was lower than that of wild-type mice under normal conditions, and this difference was maintained after salt loading, indicating a change in the set point for osmoregulation in the absence of Dp71. The increase in AVP levels detected in the SON and NH of the wild-type was not observed in Dp71-null mice following salt loading, and the increase in AVP mRNA levels in the SON was smaller in Dp71-null than in wild-type mice. This suggests that Dp71 may be involved in the functional activity of the HNHS. Its astrocyte end-feet localization emphasizes the importance of neuronal–vascular–glial interactions for the central detection of osmolality. In the SON, Dp71 may be involved in osmosensitivity and definition of the “osmostat,” whereas, in the neurohypopohysis, it may be involved in fine-tuning AVP release. © 2009 Wiley-Liss, Inc.
Databáze: OpenAIRE
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