Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro
| Autor: | Karin Séron, Khaled Rashed, Gaspard Deloison, Yves Rouillé, Marie-Emmanuelle Sahuc, Priscille Brodin, Noémie Calland |
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| Rok vydání: | 2014 |
| Předmět: |
Flavonoids
Nutrition and Dietetics Nutrition. Foods and food supply Hepatitis C virus Isovitexin Solanum rantonnetii Vitexin Medicine (miscellaneous) Ether Biology Pharmacology medicine.disease_cause Virus In vitro chemistry.chemical_compound Biochemistry chemistry HCV medicine TX341-641 Aerial parts Antiviral activity Quercetin Kaempferol Food Science |
| Zdroj: | Journal of Functional Foods, Vol 11, Iss, Pp 185-191 (2014) |
| ISSN: | 1756-4646 |
| Popis: | The anti-hepatitis C virus (HCV) activity of Solanum rantonnetii aerial parts and identity of the bioactive compounds present were evaluated. This led to identification of kaempferol 8-methyl ether (1), quercetin 3-methyl ether (2), kaempferol (3), vitexin (4), isovitexin (5), kaempferol 3-O-α-rhamnoside (6), kaempferol 3-O-β-glucoside (7), and quercetin 3-O-β-galactoside (8). The results showed that S. rantonnetii extract has a significant anti-HCV activity, with a half-maximal inhibiting concentration of 7 µg/ml and no apparent toxicity. Furthermore, the extract was shown to inhibit HCV entry, with no effect when added after infection. Compounds (1 and 2) isolated from the extract showed a strong anti-HCV activity and a third compound, compound 3, had a moderate anti-HCV activity. This is the first report for anti-HCV activity of S. rantonnetii and its bioactive compounds. These results suggest that S. rantonnetii extract could become a molecular template for the development of new antiviral therapy for HCV infection. |
| Databáze: | OpenAIRE |
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