Efficacy of topical corticosteroids on irritant skin reactions
| Autor: | Dorte W. Ramsing, Tove Agner |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythema medicine.drug_class medicine.medical_treatment Administration Topical Skin Absorption Anti-Inflammatory Agents Eczema Dermatology Dermatitis Contact Double-Blind Method medicine Immunology and Allergy Humans Glucocorticoids Chemotherapy Transepidermal water loss business.industry Sodium Dodecyl Sulfate Middle Aged Patch Tests medicine.disease Water Loss Insensible Skin reaction Treatment Outcome Toxicity Irritant contact dermatitis Corticosteroid Dermatitis Irritant Female medicine.symptom business Contact dermatitis |
| Zdroj: | Contact dermatitis. 32(5) |
| ISSN: | 0105-1873 |
| Popis: | Topical corticosteroids are frequently used in the treatment of irritant contact dermatitis (ICD). The efficacy of this treatment has, however, not been thoroughly established, and experimental studies on the topic have provided conflicting results. The aim of the present study was to evaluate the effect of potent topical corticosteroids on experimentally-induced irritant skin reactions in a double-blind, vehicle-controlled study. 16 healthy volunteers had sodium lauryl sulfate patch tests symmetrically applied to the upper arms. After removal of patch tests, a potent topical corticosteroid (betamethasone-17-valerate) was applied to the irritant skin reaction on one arm, while the corresponding vehicle was applied to the irritant skin reaction on the opposite arm 2x daily for 7 days. Reactions were evaluated by measurement of transepidermal water loss (TEWL) and erythema. After 7 days, statistically significant lower values of TEWL and erythema were found in corticosteroid-treated, compared to the vehicle-treated, skin reactions. The results indicate that topical corticosteroids improve healing of ICD. |
| Databáze: | OpenAIRE |
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