Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice

Autor: Carlos Dias Silva, Rui Daniel Prediger, Cristina Lemos, Rodrigo A. Cunha, Raquel Fonseca, Frederico C. Pereira, Ivana Jarak, Attila Köfalvi, Carlos Fontes Ribeiro, Rui A. Carvalho, Inês R. Pita, Fábio Carvalho, Ana C. Sequeira
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Anhedonia
Glucose uptake
Glutamic Acid
Motor Activity
Methamphetamine
03 medical and health sciences
chemistry.chemical_compound
Glutamatergic
Food Preferences
Mice
0302 clinical medicine
Neurochemical
Physiology (medical)
Internal medicine
medicine
Animals
Pharmacology (medical)
Maze Learning
Pharmacology
Cerebral Cortex
Aspartic Acid
Glucose Transporter Type 1
biology
Glucose Transporter Type 3
Glutamate receptor
Meth
Original Articles
Grooming
Mice
Inbred C57BL
Psychiatry and Mental health
Disease Models
Animal
030104 developmental biology
Endocrinology
Monoamine neurotransmitter
Glucose
chemistry
Brain Injuries
biology.protein
Exploratory Behavior
GLUT1
Central Nervous System Stimulants
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Zdroj: CNS neurosciencetherapeutics. 23(2)
ISSN: 1755-5949
Popis: SummaryIntroduction We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless-like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown. Aims Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i.p.), and their frontal cortical metabolic status was characterized after probing their mood and anxiety-related phenotypes 3 days postinjection. Results Methamphetamine induced depressive-like behavior, as indicated by the decreased grooming time in the splash test and by a transient decrease in sucrose preference. At this time, METH did not alter anxiety-like behavior or motor functions. Depolarization-induced glucose uptake was reduced in frontocortical slices from METH-treated mice compared to controls. Consistently, astrocytic glucose transporter (GluT1) density was lower in the METH group. A proton high rotation magic angle spinning (HRMAS) spectroscopic approach revealed that METH induced a significant decrease in N-acetyl aspartate (NAA) and glutamate levels, suggesting that METH decreased neuronal glutamatergic function in frontal cortex. Conclusions We report, for the first time, that a single METH injection triggers early self-care and hedonic deficits and impairs frontal cortical energetics in mice.
Databáze: OpenAIRE
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