Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice
Autor: | Carlos Dias Silva, Rui Daniel Prediger, Cristina Lemos, Rodrigo A. Cunha, Raquel Fonseca, Frederico C. Pereira, Ivana Jarak, Attila Köfalvi, Carlos Fontes Ribeiro, Rui A. Carvalho, Inês R. Pita, Fábio Carvalho, Ana C. Sequeira |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Anhedonia Glucose uptake Glutamic Acid Motor Activity Methamphetamine 03 medical and health sciences chemistry.chemical_compound Glutamatergic Food Preferences Mice 0302 clinical medicine Neurochemical Physiology (medical) Internal medicine medicine Animals Pharmacology (medical) Maze Learning Pharmacology Cerebral Cortex Aspartic Acid Glucose Transporter Type 1 biology Glucose Transporter Type 3 Glutamate receptor Meth Original Articles Grooming Mice Inbred C57BL Psychiatry and Mental health Disease Models Animal 030104 developmental biology Endocrinology Monoamine neurotransmitter Glucose chemistry Brain Injuries biology.protein Exploratory Behavior GLUT1 Central Nervous System Stimulants Neuroscience 030217 neurology & neurosurgery medicine.drug |
Zdroj: | CNS neurosciencetherapeutics. 23(2) |
ISSN: | 1755-5949 |
Popis: | SummaryIntroduction We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless-like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown. Aims Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i.p.), and their frontal cortical metabolic status was characterized after probing their mood and anxiety-related phenotypes 3 days postinjection. Results Methamphetamine induced depressive-like behavior, as indicated by the decreased grooming time in the splash test and by a transient decrease in sucrose preference. At this time, METH did not alter anxiety-like behavior or motor functions. Depolarization-induced glucose uptake was reduced in frontocortical slices from METH-treated mice compared to controls. Consistently, astrocytic glucose transporter (GluT1) density was lower in the METH group. A proton high rotation magic angle spinning (HRMAS) spectroscopic approach revealed that METH induced a significant decrease in N-acetyl aspartate (NAA) and glutamate levels, suggesting that METH decreased neuronal glutamatergic function in frontal cortex. Conclusions We report, for the first time, that a single METH injection triggers early self-care and hedonic deficits and impairs frontal cortical energetics in mice. |
Databáze: | OpenAIRE |
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