Deep Cerebellar Nuclei Functional Connectivity with Cerebral Cortex in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic–Clonic Seizures: a Resting-State fMRI Study
| Autor: | Liluo Nie, Jian Li, Jinou Zheng, Xiulin Liang, Weiwei Chang, Zongxia Lv, Yanchun Jiang, Xiaomin Pang |
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| Rok vydání: | 2021 |
| Předmět: |
Precuneus
Deep cerebellar nuclei 050105 experimental psychology Temporal lobe 03 medical and health sciences Superior temporal gyrus 0302 clinical medicine Seizures medicine Humans Middle frontal gyrus 0501 psychology and cognitive sciences Dynamic functional connectivity Cerebral Cortex Resting state fMRI business.industry 05 social sciences Brain Medial frontal gyrus Magnetic Resonance Imaging medicine.anatomical_structure Cerebellar Nuclei Epilepsy Temporal Lobe Neurology Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | The Cerebellum. 21:253-263 |
| ISSN: | 1473-4230 |
| DOI: | 10.1007/s12311-021-01266-3 |
| Popis: | We aimed to explore the altered functional connectivity patterns within cerebello-cerebral circuits in temporal lobe epilepsy (TLE) patients with and without focal to bilateral tonic-clonic seizures (FBTCS). Forty-two patients with unilateral TLE (21 with and 21 without FBTCS) and 22 healthy controls were recruited. We chose deep cerebellar nuclei as seed regions, calculated static and dynamic functional connectivity (sFC and dFC) in the patients with and without FBTCS and healthy controls, and compared sFC and dFC among the three groups. Correlation analyses were used to assess relationships between the significantly altered imaging features and patient clinical parameters. Compared to the group without FBTCS, the FBTCS group showed decreased sFC between the right dentate nuclei and left hemisphere regions including the middle frontal gyrus, superior temporal gyrus, superior medial frontal gyrus and posterior cingulate gyrus, and significantly increased dFC between the right interposed nuclei and contralateral precuneus. Relative to HCs, the FBTCS group demonstrated prominently decreased sFC between the right dentate nuclei and left middle frontal gyrus. No significant correlations between the altered imaging features and patient clinical parameters were observed. Our results suggest that the disrupted cerebello-cerebral FC might be related to cognitive impairment, epileptogenesis, and propagation of epileptic activities in patients with FBTCS. |
| Databáze: | OpenAIRE |
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