Correlation of visual function impairment and OCT findings in patients with Stargardt disease and fundus flavimaculatus

Autor: Giuseppe Querques, N. Delle Noci, Gabriel Coscas, E.H. Souied, M. Voigt, G. Soubrane, C. Iaculli, Rosa Prato
Přispěvatelé: Querques, G, Prato, R, Iaculli, C, Voigt, M, Delle Noci, N, Coscas, G, Soubrane, G, Souied, Eh
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Adult
Male
medicine.medical_specialty
Visual acuity
genetic structures
Fundus Oculi
Vision Disorders
Visual Acuity
Fixation
Ocular
imaging methods (CT
FA
ICG
MRI
OCT
RTA
SLO
ultrasound) • retinal degenerations: hereditary • photoreceptors: visual performance [Keywords]
Correlation
03 medical and health sciences
0302 clinical medicine
Foveal
Ophthalmology
medicine
Humans
Prospective Studies
Pigment Epithelium of Eye
Prospective cohort study
Aged
Retina
business.industry
Retinal Degeneration
General Medicine
Middle Aged
medicine.disease
eye diseases
Stargardt disease
medicine.anatomical_structure
Case-Control Studies
Fixation (visual)
030221 ophthalmology & optometry
Visual Field Tests
Optometry
Female
sense organs
medicine.symptom
business
Microperimetry
Tomography
Optical Coherence
030217 neurology & neurosurgery
Photoreceptor Cells
Vertebrate
Zdroj: Scopus-Elsevier
Università Vita-Salute San Raffaele-IRIS
Popis: Purpose To investigate the relationship between morphologic lesions of the retina and functional abnormalities in patients with Stargardt disease (STGD) and fundus flavimaculatus (FFM). DESIGN. Case-controlled, prospective, comparative observational study. Methods A complete ophthalmologic examination, including best-corrected visual acuity (BCVA) and optical coherence tomography (OCT), was performed in 61 eyes of 32 consecutive patients with STGD/FFM and in 60 eyes of 30 matched healthy control subjects. Furthermore, fundus-related perimetry was performed in 12 of the affected eyes. Results The age ranged from 21 to 71 years in STGD/FFM patients and from 21 to 72 years in controls. BCVA ranged from 20/20 to 20/400 and from 20/20 to 20/32, respectively, in STGD/FFM patients and in controls. A foveal thinning was found by OCT Stratus in almost all cases (average 160 μm) compared with controls (average 210 μm) (ppConclusions In this series, lower visual acuity and unstable fixation correlated with a greater transverse foveal thinning. OCT and fundus-related perimetry may be useful tools in STGD/FFM patients.
Databáze: OpenAIRE
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