How many histological levels should be examined from tissue blocks originating in cone biopsy and large loop excision of the transformation zone specimens of cervix?
| Autor: | Mark K Heatley |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Biopsy Zona Short Report Uterine Cervical Neoplasms Cervix Uteri Cervical intraepithelial neoplasia Sensitivity and Specificity Pathology and Forensic Medicine medicine Carcinoma Humans Cervix Cervical cancer Cervical screening biology medicine.diagnostic_test business.industry Squamocolumnar Junction General Medicine medicine.disease biology.organism_classification Uterine Cervical Dysplasia medicine.anatomical_structure Female business |
| Zdroj: | Journal of clinical pathology. 54(8) |
| ISSN: | 0021-9746 |
| Popis: | Aims—To establish the value of examining additional histological levels in cone biopsy and large loop excision of the transformation zone (LLETZ) specimens of cervix. Methods—Three deeper levels were examined from 200 consecutive cone biopsy and LLETZ specimens reported by a single pathologist. Results—Examination of the first deeper level resulted in cervical intraepithelial neoplasia (CIN) being identified for the first time in five cases and in CIN1 being upgraded in five more. Invasive cancer was discovered in two cases that had shown high grade CIN initially. Conclusion—Examination of a single further level appears to be sufficient in those patients in whom a specimen is compromised because epithelium including the squamocolumnar junction is missing, or if there is a discrepancy between the histological findings and the preceding colposcopic or cytological history. If invasive disease is suspected on the basis of the cytological, colposcopic, or histological features, one or preferably two further levels should be examined. Key Words: cervix uteri • quality control • diagnosis |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|