Arthrogryposis multiplex congenita: twenty-three cases in an Arab kindred
| Autor: | Yehuda Matoth, Amnon Fried, Avinoam Adam, Uriel Sandbank, Theodore Najenson, Emanuel Lebenthal, Solly Barnard Shochet, Moshe Seelenfreund |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
musculoskeletal diseases
Adult Heart Defects Congenital Male Wrist Joint Pediatrics medicine.medical_specialty Heart disease Adolescent Knee Joint Neural Conduction Genes Recessive Consanguinity Nerve Fibers Myelinated Fructose-Bisphosphate Aldolase Elbow Joint Medicine Humans Child Creatine Kinase Muscle contracture High rate Arthrogryposis Arthrogryposis multiplex congenita business.industry Electromyography Arabia Muscles Homozygote Muscle weakness Infant medicine.disease Pedigree Child Preschool Pediatrics Perinatology and Child Health Female Autopsy medicine.symptom business Ankle Joint |
| Zdroj: | Pediatrics. 46(6) |
| ISSN: | 0031-4005 |
| Popis: | An Arab kindred is described in which 17 males and six females had clinical manifestations of arthrogryposis multiplex congenita (AMC). The syndrome, which is present at birth, is expressed mainly by flexion and extension contractures of the knees and elbows, with muscle weakness around the involved joints. Six patients had associated congenital heart disease which caused death in five. One patient was mentally retarted. Electromyographic studies failed to reveal any participation of the lower motor neurons. Histological and biochemical findings suggest a myogenicetiology. The pedigree data, being characterized by a very high rate of consanguinity among the parents of the affected and the existence of 20 normal off-spring of three affected males, demonstrate the autosomal recessive mode of inheritance, which is in contrast to the dominant pattern observed in neurogenic AMC. |
| Databáze: | OpenAIRE |
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