Association between plasminogen activator inhibitor-1 -675 4G/5G polymorphism and sepsis: a meta-analysis
| Autor: | Hongfeng Zhou, Li Li, Weifeng Li, Wenjie Huang, Wei-Zhi Nie, Weifeng Yuan |
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| Rok vydání: | 2012 |
| Předmět: |
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Critical Care and Emergency Medicine Non-Clinical Medicine Clinical Research Design Epidemiology lcsh:Medicine Bioinformatics Polymorphism Single Nucleotide Sepsis chemistry.chemical_compound Polymorphism (computer science) Plasminogen Activator Inhibitor 1 medicine Odds Ratio Genetics Humans lcsh:Science Biology Genetic Association Studies Multidisciplinary Health Care Policy business.industry lcsh:R Health Risk Analysis Odds ratio medicine.disease chemistry Plasminogen activator inhibitor-1 Meta-analysis Genetic Epidemiology Immunology Publication ethics Genetic Polymorphism Medicine lcsh:Q Clinical Immunology Meta-Analyses 4g 5g polymorphism business Plasminogen activator Publication Bias Population Genetics Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 1, p e54883 (2013) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: Several studies have evaluated the association between plasminogen activator inhibitor-1 (PAI-1) -675 4G/5G polymorphism and sepsis in different populations. However, the available results are conflicting. METHODS: A search of Pubmed and EMBASE databases was performed to identify relevant studies for inclusion in the meta-analysis. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were determined using a random-effects model. RESULTS: Twelve case-control studies and three cohort studies were included. Overall, a significant association between 4G/5G polymorphism and sepsis risk was observed for 4G/4G vs. 4G/5G +5G/5G (OR = 1.30, 95% CI 1.08-1.56, P = 0.006). In addition, there was a significant association between PAI-1 4G/5G polymorphism and sepsis-related mortality (OR = 1.72, 95% CI 1.27-2.33, P = 0.0005). In subgroup analyses, increased sepsis risk and mortality risk were found in Caucasians and in patients with sepsis. CONCLUSIONS: This meta-analysis suggested that the PAI-1 -675 4G/5G polymorphism was a risk factor for sepsis and sepsis mortality. |
| Databáze: | OpenAIRE |
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