Postprandial prolactin suppression appears absent in antipsychotic-treated male patients
| Autor: | Pal B. Szecsi, Klara Coello, Nikolaj Bak, Filip K. Knop, Brian V. Broberg, Birgitte Søgaard, Anna Madsen, Bjørn H Ebdrup, Henrik Lublin, Henrik B. Mortensen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism medicine.medical_treatment Body Mass Index Young Adult Endocrinology Risk Factors Internal medicine Diabetes mellitus medicine Antipsychotics Humans Ingestion Antipsychotic Meal-response Biological Psychiatry Morning Endocrine and Autonomic Systems business.industry Males Fasting Middle Aged Postprandial Period medicine.disease Prolactin Hyperprolactinemia Psychiatry and Mental health Postprandial Case-Control Studies Schizophrenia Waist Circumference business Schizophrenia spectrum Body mass index Antipsychotic Agents |
| Zdroj: | BASE-Bielefeld Academic Search Engine |
| ISSN: | 0306-4530 |
| Popis: | Summary Introduction Hyperprolactinemia is a common side-effect of antipsychotic treatment. Antipsychotics and hyperprolactinemia are both considered risk factors of metabolic disturbances and diabetes. Investigations on prolactin response to meal ingestion in antipsychotic-treated patients are missing. Material and methods In a case-control design, 49 antipsychotic-treated, clinically stable, non-diabetic, schizophrenia spectrum male patients were compared with 93 healthy male controls by age (33.1, SD 7.4 vs. 32.9, SD 6.6 years), body mass index (26.2, SD 4.6 vs. 26.1, SD 3.9 kg/m 2 ) and waist circumference (96.4, SD 13.0 vs. 96.7, SD 11.9 cm). Serum-prolactin was measured in the morning and 90 min after ingestion of a standardized liquid meal (2268 kJ). Results Fasting prolactin levels varied considerably, and mean fasting prolactin levels did not significantly differ between patients and controls (12.33, SD 11.58 vs. 10.06, SD 8.67 ng/ml, p = 0.623). In the controls, postprandial serum prolactin was significantly reduced ( Δ −2.53, SD 9.75 ng/ml, p = 0.016). In antipsychotic-treated patients postprandial serum prolactin tended to increase ( Δ 2.62, SD 10.96 ng/ml, p = 0.081). Analyses of subgroups based on the prolactinogenic liability of their antipsychotic treatment indicated 22 to 65% higher postprandial prolactin levels with high and intermediate prolactinogenic antipsychotics. Discussion A physiological postprandial suppression of serum prolactin appears absent in antipsychotic-treated males. Marked variability in fasting prolactin levels may reflect individual variations in the diurnal cycle. Uniform acquisition procedures accounting for diurnal variation and food intake may enhance reliability of prolactin levels in antipsychotic-treated male patients. |
| Databáze: | OpenAIRE |
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